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    CPT1B carnitine palmitoyltransferase 1B [ Bos taurus (domestic cattle) ]

    Gene ID: 509459, updated on 12-Oct-2024

    Summary

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    Official Symbol
    CPT1Bprovided by VGNC
    Official Full Name
    carnitine palmitoyltransferase 1Bprovided by VGNC
    Primary source
    VGNC:VGNC:27677
    See related
    BGD:BT10800; Ensembl:ENSBTAG00000016048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CPT1B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (119888738..119897109, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 7B Neighboring gene synaptonemal complex central element protein 3 Neighboring gene choline kinase beta Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GW501516-activated PPARd maintained the correlation between lipolysis and lipogenesis by enhancing PEPCK and CPT1 to improve bovine embryo quality.
      Title: The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.
    2. Suppression of CPT1B and induction of SCD and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
      Title: Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid.
    3. This study evaluated the effects of nonesterified fatty acids and glucose on carnitine palmitoyltransferase-I (CPT-I) mRNA expression in cultured bovine hepatocytes using real-time reverse transcription polymerase chain reaction and ELISA methods.
      Title: Effect of NEFA and glucose levels on CPT-I mRNA expression and translation in cultured bovine hepatocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables carnitine O-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carnitine O-palmitoyltransferase 1, muscle isoform
    Names
    CPT I
    CPT1-M
    CPTI-M
    carnitine palmitoyltransferase 1B (muscle)
    NP_001029521.1
    XP_015326942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034349.2 → NP_001029521.1  carnitine O-palmitoyltransferase 1, muscle isoform

      See identical proteins and their annotated locations for NP_001029521.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123511
      UniProtKB/Swiss-Prot
      Q08DY3, Q58DK1
      UniProtKB/TrEMBL
      A0AAA9THF6
      Related
      ENSBTAP00000021357.4, ENSBTAT00000021357.6
      Conserved Domains (2) summary
      pfam00755
      Location:172 → 760
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      119888738..119897109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015471456.3 → XP_015326942.1  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1

      UniProtKB/TrEMBL
      A0AAA9THF6
      Conserved Domains (2) summary
      pfam00755
      Location:172 → 744
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 46
      CPT_N; Carnitine O-palmitoyltransferase N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58DK1.1 GenPept UniProtKB/Swiss-Prot:Q58DK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.