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    PPP2R2B protein phosphatase 2 regulatory subunit Bbeta [ Bos taurus (domestic cattle) ]

    Gene ID: 509290, updated on 18-Aug-2024

    Summary

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    Official Symbol
    PPP2R2Bprovided by VGNC
    Official Full Name
    protein phosphatase 2 regulatory subunit Bbetaprovided by VGNC
    Primary source
    VGNC:VGNC:33256
    See related
    BGD:BT21276; Ensembl:ENSBTAG00000001862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PPP2R2B in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (57796200..58305681, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447556 Neighboring gene G protein-coupled receptor 151 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene serine/threonine kinase 32A Neighboring gene microRNA mir-2284y-7 Neighboring gene dihydropyrimidinase like 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C. Ching LC, et al. Acta Physiol (Oxf), 2013 Oct. PMID 24028645
    2. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. Sontag JM, et al. J Biol Chem, 2012 Apr 27. PMID 22403409, Free PMC Article
    3. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRPV1 activation in endothelial cells may elicit a Ca(2+) -dependent effect on PP2B-PKC signalling, which leads to dephosphorylation of eNOS
      Title: Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.
    2. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
      Title: The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139491

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-serine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
    Names
    BRbeta B-regulatory subunit of protein phosphatase 2A
    protein phosphatase 2, regulatory subunit B, beta
    NP_001259014.1
    XP_010805741.1
    XP_010805747.1
    XP_015327783.1
    XP_059744032.1
    XP_059744033.1
    XP_059744034.1
    XP_059744035.1
    XP_059744036.1
    XP_059744037.1
    XP_059744038.1
    XP_059744039.1
    XP_059744040.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272085.1 → NP_001259014.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

      See identical proteins and their annotated locations for NP_001259014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      BT020863, DV835023, EH146888, EH376346
      UniProtKB/TrEMBL
      A0A3Q1M5E1, A0A3Q1M9B9
      Related
      ENSBTAP00000065034.2, ENSBTAT00000083608.2
      Conserved Domains (2) summary
      COG5170
      Location:14 → 444
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:33 → 81
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_073586.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC118167
      Related
      ENSBTAT00000002427.4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57796200..58305681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059888050.1 → XP_059744033.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

      UniProtKB/TrEMBL
      A0AAA9SQ04

    2. XM_059888051.1 → XP_059744034.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X4

      UniProtKB/TrEMBL
      A0AAA9S0F3, A0AAA9SQ04
      Related
      ENSBTAP00000078444.1, ENSBTAT00000100343.1

    3. XM_010807439.3 → XP_010805741.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

      See identical proteins and their annotated locations for XP_010805741.1

      UniProtKB/TrEMBL
      A0A3Q1M5E1, A0AAA9SP76
      Related
      ENSBTAP00000088118.1, ENSBTAT00000104122.1
      Conserved Domains (2) summary
      COG5170
      Location:88 → 504
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:93 → 141
      7WD40; WD40 repeat [structural motif]

    4. XM_059888049.1 → XP_059744032.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1

    5. XM_010807445.4 → XP_010805747.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X7

      See identical proteins and their annotated locations for XP_010805747.1

      UniProtKB/TrEMBL
      A0A3Q1N515, A0AAA9SBE3
      Related
      ENSBTAP00000081215.1, ENSBTAT00000111445.1
      Conserved Domains (2) summary
      COG5170
      Location:25 → 441
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:30 → 78
      7WD40; WD40 repeat [structural motif]

    6. XM_059888056.1 → XP_059744039.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X9

      UniProtKB/TrEMBL
      A0A3Q1MH72, A0A3Q1N515
      Related
      ENSBTAP00000068406.1, ENSBTAT00000067103.2

    7. XM_059888055.1 → XP_059744038.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X8

      UniProtKB/TrEMBL
      A0A3Q1N515

    8. XM_059888053.1 → XP_059744036.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6

      UniProtKB/TrEMBL
      A0A3Q1N515

    9. XM_059888057.1 → XP_059744040.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X11

    10. XM_059888052.1 → XP_059744035.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MJU7, A0A3Q1N515
      Related
      ENSBTAP00000071664.2, ENSBTAT00000074552.2

    11. XM_059888054.1 → XP_059744037.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6

      UniProtKB/TrEMBL
      A0A3Q1N515

    12. XM_015472297.2 → XP_015327783.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X10

      UniProtKB/TrEMBL
      A0A3Q1N515
      Conserved Domains (3) summary
      COG5170
      Location:3 → 416
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:5 → 53
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:168 → 412
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014879.2: Suppressed sequence

      Description
      NM_001014879.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E9Q7.1 GenPept UniProtKB/Swiss-Prot:Q5E9Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials