NUCB2 nucleobindin 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: NUCB2provided by VGNC
Official Full Name: nucleobindin 2provided by VGNC
Primary source: VGNC:VGNC:32319
See related: BGD:BT22198; Ensembl:ENSBTAG00000017468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (35156665..35197996, complement)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings first revealed the genetic effects of NUCB2 on the milk traits in dairy cows, and suggested that the significant SNPs could be used in genomic selection to improve the accuracy of selection for dairy cattle breeding
Title: Single Nucleotide Polymorphisms of NUCB2 and their Genetic Associations with Milk Production Traits in Dairy Cows.
Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.
Title: Novel SNPs of the bovine NUCB2 gene and their association with growth traits in three native Chinese cattle breeds.

Submit: New GeneRIF Correction

General gene information

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Markers

NUCB2 (e-PCR)
- UniSTS:278856

MARC_16009-16010:1017078784:5 (e-PCR)
- UniSTS:267933

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nucleobindin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075381.1 → NP_001068849.1 nucleobindin-2 precursor

See identical proteins and their annotated locations for NP_001068849.1

Status: PROVISIONAL

Source sequence(s)

BC122643

UniProtKB/TrEMBL

F6Q8A8, Q0IIH5

Related

ENSBTAP00000023221.6, ENSBTAT00000023221.7

Conserved Domains (2) summary

pfam13499
Location:247 → 321

EF-hand_7; EF-hand domain pair

cl08302
Location:250 → 321

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

Range

35156665..35197996 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005215930.4 → XP_005215987.1 nucleobindin-2 isoform X1

See identical proteins and their annotated locations for XP_005215987.1

UniProtKB/TrEMBL

F6Q8A8, Q0IIH5

Conserved Domains (2) summary

pfam13499
Location:247 → 321

EF-hand_7; EF-hand domain pair

cl08302
Location:250 → 321

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...