Tfr2 transferrin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfr2provided by MGI
Official Full Name: transferrin receptor 2provided by MGI
Primary source: MGI:MGI:1354956
See related: Ensembl:ENSMUSG00000029716 AllianceGenome:MGI:1354956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trfr2
Summary: Predicted to enable co-receptor binding activity and transferrin receptor activity. Acts upstream of or within multicellular organismal-level iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in liver lobe; mesonephros; and urinary system. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 109.9), liver E18 (RPKM 30.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.57 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137568127..137586344)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137569822..137588081)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow.
Title: Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow.
Transferrin receptor 2 mitigates periodontitis-driven alveolar bone loss.
Title: Transferrin receptor 2 mitigates periodontitis-driven alveolar bone loss.
Deregulating iron-erythropoiesis regulation: transferrin receptor 2 as potential target for treating anemia in CKD.
Title: Deregulating iron-erythropoiesis regulation: transferrin receptor 2 as potential target for treating anemia in CKD.
Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis.
Title: Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis.
Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion-independent a murine model of transfusion-dependent beta-thalassemia.
Title: Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion-independent a murine model of transfusion-dependent β-thalassemia.
Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model.
Title: Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model.
Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload.
Title: Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload.
Deletion of bone marrow Tfr2 ameliorates anemia and iron overload in a murine model of transfusion-independent thalassemia.
Title: Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model.
Tfr2 is a key regulator of brain iron homeostasis and propose a role for Tfr2 alpha in the regulation of anxiety circuits.
Title: Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse.
these data confirm the role of Tfr2a in modulation of erythropoiesis and of Tfr2b in favoring iron availability for erythropoiesis
Title: Altered Erythropoiesis in Mouse Models of Type 3 Hemochromatosis.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	IEA Inferred from Electronic Annotation more info
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferrin receptor activity	ISO Inferred from Sequence Orthology more info
enables transferrin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to iron ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in endocytic iron import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic iron import into cell	IEA Inferred from Electronic Annotation more info
involved_in endocytic iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular iron ion homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	IEA Inferred from Electronic Annotation more info
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of HFE-transferrin receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of HFE-transferrin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transferrin receptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289507.3 → NP_001276436.2 transferrin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC148018

Consensus CDS

CCDS39333.1

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3

Related

ENSMUSP00000142502.2, ENSMUST00000198783.5

Conserved Domains (3) summary

cd02128
Location:206 → 396

PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

pfam04253
Location:664 → 788

TFR_dimer; Transferrin receptor-like dimerization domain
NM_001289509.2 → NP_001276438.1 transferrin receptor protein 2

See identical proteins and their annotated locations for NP_001276438.1

Status: VALIDATED

Source sequence(s)

AC148018

Consensus CDS

CCDS39333.1

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3

Related

ENSMUSP00000142478.2, ENSMUST00000199054.5

Conserved Domains (3) summary

cd02128
Location:206 → 396

PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

pfam04253
Location:664 → 788

TFR_dimer; Transferrin receptor-like dimerization domain
NM_001289511.2 → NP_001276440.1 transferrin receptor protein 2

See identical proteins and their annotated locations for NP_001276440.1

Status: VALIDATED

Source sequence(s)

AC148018

Consensus CDS

CCDS39333.1

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3

Related

ENSMUSP00000142814.2, ENSMUST00000196471.5

Conserved Domains (3) summary

cd02128
Location:206 → 396

PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

pfam04253
Location:664 → 788

TFR_dimer; Transferrin receptor-like dimerization domain
NM_001359206.2 → NP_001346135.1 transferrin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC148018

Consensus CDS

CCDS39333.1

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3

Related

ENSMUSP00000142720.2, ENSMUST00000198866.5

Conserved Domains (3) summary

cd02128
Location:206 → 396

PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

pfam04253
Location:664 → 788

TFR_dimer; Transferrin receptor-like dimerization domain
NM_001425505.1 → NP_001412434.1 transferrin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC148018

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
NM_001425506.1 → NP_001412435.1 transferrin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC148018

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
NM_001425507.1 → NP_001412436.1 transferrin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC148018

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
NM_015799.5 → NP_056614.3 transferrin receptor protein 2

See identical proteins and their annotated locations for NP_056614.3

Status: VALIDATED

Source sequence(s)

AC148018

Consensus CDS

CCDS39333.1

UniProtKB/Swiss-Prot

Q920I6, Q99MQ9, Q9CPT2, Q9JKX3

Related

ENSMUSP00000031729.9, ENSMUST00000031729.13

Conserved Domains (3) summary

cd02128
Location:206 → 396

PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

pfam04253
Location:664 → 788

TFR_dimer; Transferrin receptor-like dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137568127..137586344

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_152864.1: Suppressed sequence

Description

NR_152864.1: This RefSeq has been removed because currently there is insufficient support for this transcript.