TDP2 tyrosyl-DNA phosphodiesterase 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TDP2provided by VGNC
Official Full Name: tyrosyl-DNA phosphodiesterase 2provided by VGNC
Primary source: VGNC:VGNC:35714
See related: Ensembl:ENSBTAG00000000365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: TTRAP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (33082758..33094886)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 5'-tyrosyl-DNA phosphodiesterase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosyl-DNA phosphodiesterase 2

Names: 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; tyr-DNA phosphodiesterase 2

NP_001098811.1

EC 3.1.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105341.1 → NP_001098811.1 tyrosyl-DNA phosphodiesterase 2

See identical proteins and their annotated locations for NP_001098811.1

Status: PROVISIONAL

Source sequence(s)

BC134603

UniProtKB/Swiss-Prot

A7YWI9

Related

ENSBTAP00000000472.5, ENSBTAT00000000472.6

Conserved Domains (2) summary

cd09080
Location:116 → 360

TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains

cd14344
Location:27 → 63

UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins