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    LARGE1 LARGE xylosyl- and glucuronyltransferase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 506466, updated on 10-Oct-2024

    Summary

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    Official Symbol
    LARGE1provided by VGNC
    Official Full Name
    LARGE xylosyl- and glucuronyltransferase 1provided by VGNC
    Primary source
    VGNC:VGNC:54444
    See related
    BGD:BT16788; Ensembl:ENSBTAG00000021953
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LARGE1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (71806170..72416116, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446723 Neighboring gene protein HP-20 homolog Neighboring gene uncharacterized LOC101905163 Neighboring gene transfer RNA arginine (anticodon CCU)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables xylosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    xylosyl- and glucuronyltransferase LARGE1
    NP_001192517.1
    XP_005206837.1
    XP_024847258.1
    XP_059742187.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205588.1 → NP_001192517.1  xylosyl- and glucuronyltransferase LARGE1

      See identical proteins and their annotated locations for NP_001192517.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      A0AAA9TNJ8, E1BDI0
      Related
      ENSBTAP00000029269.6, ENSBTAT00000029269.7
      Conserved Domains (3) summary
      cd06431
      Location:138 → 417
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:136 → 386
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:473 → 742
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      71806170..72416116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005206780.5 → XP_005206837.1  xylosyl- and glucuronyltransferase LARGE1 isoform X1

      See identical proteins and their annotated locations for XP_005206837.1

      UniProtKB/TrEMBL
      A0AAA9TNJ8, E1BDI0
      Conserved Domains (3) summary
      cd06431
      Location:138 → 417
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:136 → 386
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:473 → 742
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    2. XM_059886204.1 → XP_059742187.1  xylosyl- and glucuronyltransferase LARGE1 isoform X1

      UniProtKB/TrEMBL
      E1BDI0

    3. XM_024991490.2 → XP_024847258.1  xylosyl- and glucuronyltransferase LARGE1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TNJ8
      Conserved Domains (2) summary
      cd06431
      Location:35 → 314
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      pfam13896
      Location:370 → 639
      Glyco_transf_49; Glycosyl-transferase for dystroglycan
    Nucleotide Protein Strain
    Heading Accession and Version

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