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    GSR glutathione-disulfide reductase [ Bos taurus (domestic cattle) ]

    Gene ID: 506406, updated on 4-Oct-2024

    Summary

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    Official Symbol
    GSRprovided by VGNC
    Official Full Name
    glutathione-disulfide reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:29682
    See related
    BGD:BT27146; Ensembl:ENSBTAG00000007115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GSR in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (26801918..26846927, complement)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene microRNA mir-2399 Neighboring gene general transcription factor IIE subunit 2 Neighboring gene small integral membrane protein 18 Neighboring gene large ribosomal subunit protein uL24-like Neighboring gene UBX domain protein 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy. Abd Ellah MR, et al. J Vet Med Sci, 2008 Aug. PMID 18772567
    2. Synteny mapping of human chromosome 8 loci in cattle. Threadgill DW, et al. Anim Genet, 1991. PMID 1909844
    3. Glutathione content and expression of proteins involved with glutathione metabolism differs in longissimus dorsi, subcutaneous adipose, and liver tissues of finished vs. growing beef steers. Huang J, et al. J Anim Sci, 2018 Dec 3. PMID 30204884, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glutathione-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione reductase, mitochondrial
    Names
    glutathione reductase
    NP_001107662.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114190.2 → NP_001107662.1  glutathione reductase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      DV820297, DV884056, EE253355, EH148178, EV753873, NKLS02000027
      UniProtKB/TrEMBL
      A0AAA9TCS2, E1BKZ1
      Related
      ENSBTAP00000009363.6, ENSBTAT00000009363.7
      Conserved Domains (4) summary
      TIGR01421
      Location:61 → 519
      gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
      pfam00070
      Location:230 → 306
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:409 → 517
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:181 → 243
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26801918..26846927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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