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    ARHGEF4 Rho guanine nucleotide exchange factor 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 505852, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ARHGEF4provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 4provided by VGNC
    Primary source
    VGNC:VGNC:55325
    See related
    BGD:BT17855; Ensembl:ENSBTAG00000015834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (1533321..1864857)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene COMM domain-containing protein 6-like Neighboring gene APC membrane recruitment protein 3 Neighboring gene family with sequence similarity 168 member B Neighboring gene pleckstrin homology domain containing B2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 4
    Names
    Rho guanine nucleotide exchange factor (GEF) 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192073.2 → NP_001179002.2  rho guanine nucleotide exchange factor 4

      Status: VALIDATED

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      A0A3Q1LJ25, A0AAA9T929
      Related
      ENSBTAP00000059272.2, ENSBTAT00000086719.2
      Conserved Domains (3) summary
      cd11973
      Location:1415 → 1487
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:1524 → 1703
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01224
      Location:1708 → 1847
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      1533321..1864857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892236.1 → XP_059748219.1  rho guanine nucleotide exchange factor 4 isoform X1

    2. XM_059892237.1 → XP_059748220.1  rho guanine nucleotide exchange factor 4 isoform X2

      Related
      ENSBTAP00000021041.6, ENSBTAT00000021041.7

    3. XM_059892244.1 → XP_059748227.1  rho guanine nucleotide exchange factor 4 isoform X3

    4. XM_059892240.1 → XP_059748223.1  rho guanine nucleotide exchange factor 4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials