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    MCM4 minichromosome maintenance complex component 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 504367, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MCM4provided by VGNC
    Official Full Name
    minichromosome maintenance complex component 4provided by VGNC
    Primary source
    VGNC:VGNC:106815
    See related
    BGD:BT25424; Ensembl:ENSBTAG00000017021
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (19551825..19563217)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene H3 histone, family 3C Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene nucleolar RNA helicase 2-like Neighboring gene ubiquitin conjugating enzyme E2 V2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138087, MGC140484

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA unwinding involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM4
    Names
    MCM4 minichromosome maintenance deficient 4
    NP_001068626.1
    XP_024857211.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075158.1 → NP_001068626.1  DNA replication licensing factor MCM4

      See identical proteins and their annotated locations for NP_001068626.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118099
      UniProtKB/TrEMBL
      E1BFZ9, Q148N1
      Related
      ENSBTAP00000049149.4, ENSBTAT00000054380.4
      Conserved Domains (4) summary
      cd00009
      Location:478 → 623
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00350
      Location:240 → 743
      MCM; minichromosome maintenance proteins
      pfam11679
      Location:4 → 47
      DUF3275; Protein of unknown function (DUF3275)
      pfam14551
      Location:139 → 260
      MCM_N; MCM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19551825..19563217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025001443.2 → XP_024857211.1  DNA replication licensing factor MCM4 isoform X1

      UniProtKB/TrEMBL
      E1BFZ9
      Related
      ENSBTAP00000079802.1, ENSBTAT00000122009.1
      Conserved Domains (3) summary
      smart00350
      Location:240 → 743
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:139 → 237
      MCM_N; MCM N-terminal domain
      cl28034
      Location:3 → 145
      Herpes_ICP4_N; Herpesvirus ICP4-like protein N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials