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    Angptl3 angiopoietin-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502970, updated on 2-Nov-2024

    Summary

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    Symbol
    Angptl3provided by RGD
    Full Name
    angiopoietin-like 3provided by RGD
    Primary source
    RGD:1564505
    See related
    EnsemblRapid:ENSRNOG00000008638 AllianceGenome:RGD:1564505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable growth factor activity; integrin binding activity; and phospholipase inhibitor activity. Involved in response to hormone. Predicted to be located in Golgi apparatus; cell surface; and early endosome. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1507.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Angptl3 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (118818494..118825531)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (113703007..113710044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (117698590..117706729)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 15, pseudogene 2 Neighboring gene ubiquitin specific peptidase 1 Neighboring gene dedicator of cytokinesis 7 Neighboring gene noelin-like Neighboring gene ribosomal protein L15, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia. Zhao Y, et al. J Pharmacol Exp Ther, 2021 Mar. PMID 33443084
    2. The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone. Fugier C, et al. J Biol Chem, 2006 Apr 28. PMID 16505486
    3. Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. Shimamura M, et al. Biochem Biophys Res Commun, 2003 Feb 7. PMID 12565906
    4. ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states. Inukai K, et al. Biochem Biophys Res Commun, 2004 May 14. PMID 15094378
    5. Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. Ono M, et al. J Biol Chem, 2003 Oct 24. PMID 12909640

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia.
      Title: RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acylglycerol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipoprotein lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025065.2 → NP_001020236.1  angiopoietin-related protein 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001020236.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      Q5I0L8
      Conserved Domains (1) summary
      cl00085
      Location:241 → 311
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    2. NM_001399252.1 → NP_001386181.1  angiopoietin-related protein 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRL4, F7FHP0
      Related
      ENSRNOP00000011486.5, ENSRNOT00000011486.8
      Conserved Domains (2) summary
      COG1196
      Location:90 → 205
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00087
      Location:241 → 453
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    3. NM_001399253.1 → NP_001386182.1  angiopoietin-related protein 3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRL5
      Conserved Domains (1) summary
      COG1196
      Location:63 → 206
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      118818494..118825531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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