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    Mettl5 methyltransferase 5, N6-adenosine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502632, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mettl5provided by RGD
    Official Full Name
    methyltransferase 5, N6-adenosineprovided by RGD
    Primary source
    RGD:1566062
    See related
    EnsemblRapid:ENSRNOG00000008469 AllianceGenome:RGD:1566062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566062
    Summary
    Predicted to enable S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to be located in several cellular components, including fibrillar center; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 205.1), Heart (RPKM 202.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl5 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75033605..75046359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54625790..54638066, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56101597..56113823, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene kelch-like family member 23 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 5 Neighboring gene uncharacterized LOC134486377 Neighboring gene myosin IIIB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic Variants in METTL5 Cause Autosomal-Recessive Intellectual Disability and Microcephaly. Richard EM, et al. Am J Hum Genet, 2019 Oct 3. PMID 31564433, Free PMC Article
    2. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. van Tran N, et al. Nucleic Acids Res, 2019 Sep 5. PMID 31328227, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187943

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine-N6-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rRNA N6-adenosine-methyltransferase METTL5
    Names
    methyltransferase like 5
    methyltransferase-like protein 5
    NP_001107653.1
    XP_038961654.1
    XP_063140470.1
    XP_063140471.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114181.1 → NP_001107653.1  rRNA N6-adenosine-methyltransferase METTL5

      See identical proteins and their annotated locations for NP_001107653.1

      Status: VALIDATED

      Source sequence(s)
      BC158754, CH473949
      UniProtKB/TrEMBL
      A6HM25, B0BNB3, F7FIR4
      Related
      ENSRNOP00000011304.5, ENSRNOT00000011303.7
      Conserved Domains (1) summary
      COG2263
      Location:7 → 209
      COG2263; Predicted RNA methylase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      75033605..75046359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284401.1 → XP_063140471.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X2

      UniProtKB/TrEMBL
      A6HM25, B0BNB3, F7FIR4

    2. XM_063284400.1 → XP_063140470.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

    3. XM_039105726.2 → XP_038961654.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X3

      Conserved Domains (1) summary
      COG2263
      Location:7 → 171
      COG2263; Predicted RNA methylase [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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