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    Cyth4 cytohesin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500906, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Cyth4provided by RGD
    Official Full Name
    cytohesin 4provided by RGD
    Primary source
    RGD:1564842
    See related
    EnsemblRapid:ENSRNOG00000007679 AllianceGenome:RGD:1564842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pscd4; RGD1564842
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and intercellular bridge. Orthologous to human CYTH4 (cytohesin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 283.2), Thymus (RPKM 77.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyth4 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112032711..112057204)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110152232..110176726)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119820521..119845003)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479753 Neighboring gene uncharacterized LOC103692944 Neighboring gene Rac family small GTPase 2 Neighboring gene uncharacterized LOC134479754 Neighboring gene uncharacterized LOC102549375 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. Ogasawara M, et al. J Biol Chem, 2000 Feb 4. PMID 10652308
    2. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Hofmann I, et al. Curr Biol, 2007 Apr 17. PMID 17398095
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytohesin-4
    Names
    pleckstrin homology, Sec7 and coiled/coil domains 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130577.2 → NP_001124049.1  cytohesin-4 isoform 2

      See identical proteins and their annotated locations for NP_001124049.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSL5, D3ZHR6
      Related
      ENSRNOP00000053065.2, ENSRNOT00000056221.4
      Conserved Domains (3) summary
      cd01252
      Location:235 → 353
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam00169
      Location:239 → 351
      PH; PH domain
      pfam01369
      Location:38 → 220
      Sec7; Sec7 domain

    2. NM_001414977.1 → NP_001401906.1  cytohesin-4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSL4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112032711..112057204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079763.2 → XP_038935691.1  cytohesin-4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0A0
      Conserved Domains (2) summary
      cd01252
      Location:261 → 379
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:61 → 246
      Sec7; Sec7 domain

    2. XM_063264137.1 → XP_063120207.1  cytohesin-4 isoform X1

    3. XM_017595057.3 → XP_017450546.1  cytohesin-4 isoform X2

      Related
      ENSRNOP00000071361.3, ENSRNOT00000077256.3

    4. XM_063264138.1 → XP_063120208.1  cytohesin-4 isoform X4

      Related
      ENSRNOP00000076651.2, ENSRNOT00000105447.2

    5. XM_063264139.1 → XP_063120209.1  cytohesin-4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZK46

    6. XM_063264140.1 → XP_063120210.1  cytohesin-4 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
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