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    Map3k9 mitogen-activated protein kinase kinase kinase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500690, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Map3k9provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 9provided by RGD
    Primary source
    RGD:1562149
    See related
    EnsemblRapid:ENSRNOG00000007271 AllianceGenome:RGD:1562149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562149
    Summary
    Predicted to enable JUN kinase kinase kinase activity. Involved in cell death and positive regulation of apoptotic process. Orthologous to human MAP3K9 (mitogen-activated protein kinase kinase kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 60.4), Brain (RPKM 58.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k9 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (107155008..107220304, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101423754..101488822, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105455461..105518974, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene uncharacterized LOC102552530 Neighboring gene uncharacterized LOC134479223 Neighboring gene uncharacterized LOC102552601 Neighboring gene 60S ribosomal protein L21-like Neighboring gene uncharacterized LOC102552673 Neighboring gene pecanex 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of miR-26b-5p on cis-diamine dichloroplatinum-induced ovarian granulosa cell injury by targeting MAP3K9. Liu S, et al. In Vitro Cell Dev Biol Anim, 2020 Mar. PMID 32185607
    2. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop. Durkin JT, et al. Biochemistry, 2004 Dec 28. PMID 15610029
    3. Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells. Kim KY, et al. J Biol Chem, 2004 Jul 9. PMID 15069087
    4. CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine. Ganguly A, et al. J Neurochem, 2004 Jan. PMID 14690535
    5. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Xu Z, et al. Mol Cell Biol, 2001 Jul. PMID 11416147, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis.
      Title: IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis.
    2. Effect of miR-26b-5p on cis-diamine dichloroplatinum-induced ovarian granulosa cell injury by targeting MAP3K9.
      Title: Effect of miR-26b-5p on cis-diamine dichloroplatinum-induced ovarian granulosa cell injury by targeting MAP3K9.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 9
    Names
    mixed-lineage kinase 1
    NP_001094342.1
    XP_006240365.1
    XP_038968663.1
    XP_038968664.1
    XP_038968665.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100872.1 → NP_001094342.1  mitogen-activated protein kinase kinase kinase 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JUN9
      Conserved Domains (3) summary
      smart00219
      Location:137 → 396
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      107155008..107220304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112736.2 → XP_038968664.1  mitogen-activated protein kinase kinase kinase 9 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JUN9
      Conserved Domains (2) summary
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    2. XM_006240303.5 → XP_006240365.1  mitogen-activated protein kinase kinase kinase 9 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JUN9, F1LRA7
      Related
      ENSRNOP00000009693.4, ENSRNOT00000009693.7
      Conserved Domains (3) summary
      smart00219
      Location:137 → 396
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    3. XM_039112737.2 → XP_038968665.1  mitogen-activated protein kinase kinase kinase 9 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JUN9
      Related
      ENSRNOP00000069168.3, ENSRNOT00000083488.3
      Conserved Domains (2) summary
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 419
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    4. XM_039112735.2 → XP_038968663.1  mitogen-activated protein kinase kinase kinase 9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUN9
      Conserved Domains (2) summary
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 419
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version

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