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    Rad51b RAD51 paralog B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500679, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rad51bprovided by RGD
    Official Full Name
    RAD51 paralog Bprovided by RGD
    Primary source
    RGD:1560681
    See related
    EnsemblRapid:ENSRNOG00000059245 AllianceGenome:RGD:1560681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rad51l1; RGD1560681
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination and positive regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within blastocyst growth; positive regulation of cell population proliferation; and somite development. Predicted to be located in replication fork. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Orthologous to human RAD51B (RAD51 paralog B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 27.8), Spleen (RPKM 18.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad51b in Genome Data Viewer
    Location:
    6q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103829390..104373923)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (98096525..98640988)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102473978..103018185)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 26 Neighboring gene retinol dehydrogenase 12 Neighboring gene centrin 2 like 1 Neighboring gene uncharacterized LOC134479407 Neighboring gene uncharacterized LOC134479408 Neighboring gene uncharacterized LOC134479406 Neighboring gene uncharacterized LOC102546647 Neighboring gene ATP synthase peripheral stalk subunit d like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Holliday junction binding activity of the human Rad51B protein. Yokoyama H, et al. J Biol Chem, 2003 Jan 24. PMID 12441335
    2. Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background. Shu Z, et al. Mol Cell Biol, 1999 Dec. PMID 10567591, Free PMC Article
    3. The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy. Rodrigue A, et al. J Cell Sci, 2013 Jan 1. PMID 23108668
    4. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Masson JY, et al. Genes Dev, 2001 Dec 15. PMID 11751635, Free PMC Article
    5. Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy. Compton SA, et al. J Biol Chem, 2010 Apr 30. PMID 20207730, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein RAD51 homolog 2
    Names
    RAD51 homolog B
    RAD51-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399175.1 → NP_001386104.1  DNA repair protein RAD51 homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZYE0
      Related
      ENSRNOP00000084086.2, ENSRNOT00000105193.2
      Conserved Domains (1) summary
      cd19493
      Location:91 → 327
      Rad51B; RAD51B recombinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      103829390..104373923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594476.3 → XP_017449965.1  DNA repair protein RAD51 homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JTF1, A6HCH4

    2. XM_039113282.2 → XP_038969210.1  DNA repair protein RAD51 homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JTF1, A6HCH4
      Related
      ENSRNOP00000068685.2, ENSRNOT00000087132.3
      Conserved Domains (1) summary
      cl38936
      Location:91 → 267
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_039113283.2 → XP_038969211.1  DNA repair protein RAD51 homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JTF1, A6HCH4
      Conserved Domains (1) summary
      cl38936
      Location:91 → 252
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_017594475.3 → XP_017449964.1  DNA repair protein RAD51 homolog 2 isoform X4

      UniProtKB/TrEMBL
      A6HCH3
      Related
      ENSRNOP00000091401.2, ENSRNOT00000116880.2
      Conserved Domains (1) summary
      cd01123
      Location:83 → 277
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

    5. XM_039113281.2 → XP_038969209.1  DNA repair protein RAD51 homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AFI5
      Conserved Domains (1) summary
      cd19493
      Location:67 → 288
      Rad51B; RAD51B recombinase

    6. XM_039113277.2 → XP_038969205.1  DNA repair protein RAD51 homolog 2 isoform X1

      Conserved Domains (1) summary
      cd19493
      Location:91 → 327
      Rad51B; RAD51B recombinase

    7. XM_039113279.2 → XP_038969207.1  DNA repair protein RAD51 homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYE0
      Conserved Domains (1) summary
      cd19493
      Location:91 → 327
      Rad51B; RAD51B recombinase

    8. XM_063262317.1 → XP_063118387.1  DNA repair protein RAD51 homolog 2 isoform X7

    9. XM_039113278.2 → XP_038969206.1  DNA repair protein RAD51 homolog 2 isoform X1

      Conserved Domains (1) summary
      cd19493
      Location:91 → 327
      Rad51B; RAD51B recombinase

    RNA

    1. XR_010052147.1 RNA Sequence

    2. XR_005506073.2 RNA Sequence

      Related
      ENSRNOT00000147746.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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