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    Asprv1 aspartic peptidase, retroviral-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500243, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Asprv1provided by RGD
    Official Full Name
    aspartic peptidase, retroviral-like 1provided by RGD
    Primary source
    RGD:1560859
    See related
    EnsemblRapid:ENSRNOG00000017710 AllianceGenome:RGD:1560859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560859
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in protein processing and skin development. Orthologous to human ASPRV1 (aspartic peptidase retroviral like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Asprv1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120634793..120636265)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119077415..119078887)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118431755..118433286)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene translation machinery associated 7 homolog like 1 Neighboring gene uncharacterized LOC102554372 Neighboring gene max dimerization protein 1 Neighboring gene uncharacterized LOC134486607 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis. Bernard D, et al. J Invest Dermatol, 2005 Aug. PMID 16098038
    2. Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation. Matsui T, et al. J Biol Chem, 2006 Sep 15. PMID 16837463

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skin development ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retroviral-like aspartic protease 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399078.1 → NP_001386007.1  retroviral-like aspartic protease 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAY5
      Related
      ENSRNOP00000104522.1, ENSRNOT00000023814.7
      Conserved Domains (1) summary
      cd00303
      Location:113 → 205
      retropepsin_like; Retropepsins; pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      120634793..120636265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials