Atoh1 atonal bHLH transcription factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atoh1provided by RGD
Official Full Name: atonal bHLH transcription factor 1provided by RGD
Primary source: RGD:1565171
See related: EnsemblRapid:ENSRNOG00000006383 AllianceGenome:RGD:1565171
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565171
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin DNA binding activity. Predicted to be involved in several processes, including negative regulation of gliogenesis; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including generation of neurons; neuroblast migration; and positive regulation of inner ear auditory receptor cell differentiation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 4q31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (95241933..95244028)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (93912068..93914163)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (95498003..95500098)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Atoh1 expression levels are correlated with the arrangement, ciliary morphology, and electrophysiological characteristics of ectopic hair cell-like cells.
Title: The Atoh1 expression levels are correlated with the arrangement, ciliary morphology, and electrophysiological characteristics of ectopic hair cell-like cells.
Cochlear explants of auditory epithelia with native spiral ganglion neurons (SGNs) retained were cultured in vitro, and genetic vectors encoding Atoh1 were used to overexpress Atoh1 and induce ectopic hair-cell-like cells (EHCLCs). The neurites of the original SGNs extended toward the lesser epithelial ridge and innervated the EHCLCs.
Title: Afferent synaptogenesis between ectopic hair-cell-like cells and neurites of spiral ganglion induced by Atoh1 in mammals in vitro.
Math1 induced hair cell-like cells from lateral epithelial ridge cells mainly underwent direct trans-differentiation instead of mitosis of LER cells or newly hair cell-like cells.
Title: Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea.
Atoh1 mediates trans-differentiation of morphological and functional "ancestral" hair cells that are likely to undergo diversification in an endorgan-specific manner.
Title: Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.

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General gene information

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Markers

BB385668 (e-PCR)
- UniSTS:207968

NoName (e-PCR)
- UniSTS:546664

Atoh1 (e-PCR), detects polymorphism
- UniSTS:546664

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell fate determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gliogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inner ear receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inner ear receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor ATOH1

Names: atonal homolog 1; protein atonal homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109238.1 → NP_001102708.1 transcription factor ATOH1

See identical proteins and their annotated locations for NP_001102708.1

Status: PROVISIONAL

Source sequence(s)

CH474042

UniProtKB/TrEMBL

A6KF20, D3ZQL9

Related

ENSRNOP00000008358.3, ENSRNOT00000008358.8

Conserved Domains (1) summary

cd19713
Location:152 → 215

bHLH_TS_ATOH1; basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins