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    Agbl3 AGBL carboxypeptidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500076, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Agbl3provided by RGD
    Official Full Name
    AGBL carboxypeptidase 3provided by RGD
    Primary source
    RGD:1561995
    See related
    EnsemblRapid:ENSRNOG00000010397 AllianceGenome:RGD:1561995
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561995
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Predicted to be located in cytosol. Orthologous to human AGBL3 (AGBL carboxypeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 41.0), Kidney (RPKM 30.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agbl3 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64416139..64498987)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63448789..63535538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62293158..62377740)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene bisphosphoglycerate mutase Neighboring gene caldesmon 1 Neighboring gene uncharacterized LOC120102254 Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ Neighboring gene WD repeat domain 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. Rodriguez de la Vega M, et al. FASEB J, 2007 Mar. PMID 17244817
    2. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic carboxypeptidase 3
    Names
    ATP/GTP binding protein-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      64416139..64498987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592971.3 → XP_017448460.1  cytosolic carboxypeptidase 3 isoform X1

      UniProtKB/TrEMBL
      D3ZNU5
      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    2. XM_063286921.1 → XP_063142991.1  cytosolic carboxypeptidase 3 isoform X2

    3. XM_063286927.1 → XP_063142997.1  cytosolic carboxypeptidase 3 isoform X11

    4. XM_039108622.2 → XP_038964550.1  cytosolic carboxypeptidase 3 isoform X1

      UniProtKB/TrEMBL
      D3ZNU5
      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    5. XM_063286926.1 → XP_063142996.1  cytosolic carboxypeptidase 3 isoform X10

    6. XM_006236277.5 → XP_006236339.1  cytosolic carboxypeptidase 3 isoform X1

      See identical proteins and their annotated locations for XP_006236339.1

      UniProtKB/TrEMBL
      D3ZNU5
      Related
      ENSRNOP00000034021.6, ENSRNOT00000032077.9
      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    7. XM_039108623.2 → XP_038964551.1  cytosolic carboxypeptidase 3 isoform X4

      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    8. XM_063286928.1 → XP_063142998.1  cytosolic carboxypeptidase 3 isoform X12

    9. XM_039108624.2 → XP_038964552.1  cytosolic carboxypeptidase 3 isoform X5

      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    10. XM_039108626.2 → XP_038964554.1  cytosolic carboxypeptidase 3 isoform X7

      UniProtKB/TrEMBL
      A6IEM6
      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    11. XM_063286923.1 → XP_063142993.1  cytosolic carboxypeptidase 3 isoform X6

      UniProtKB/TrEMBL
      A6IEM6

    12. XM_063286925.1 → XP_063142995.1  cytosolic carboxypeptidase 3 isoform X9

      UniProtKB/TrEMBL
      A6IEM6

    13. XM_063286924.1 → XP_063142994.1  cytosolic carboxypeptidase 3 isoform X8

      UniProtKB/TrEMBL
      A6IEM6

    14. XM_063286922.1 → XP_063142992.1  cytosolic carboxypeptidase 3 isoform X3

    15. XM_039108627.2 → XP_038964555.1  cytosolic carboxypeptidase 3 isoform X8

      UniProtKB/TrEMBL
      A6IEM6
      Conserved Domains (2) summary
      cd06907
      Location:319 → 571
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      pfam18027
      Location:171 → 297
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    RNA

    1. XR_010066130.1 RNA Sequence

    2. XR_005503510.2 RNA Sequence

    3. XR_010066132.1 RNA Sequence

    4. XR_005503511.2 RNA Sequence

    5. XR_010066131.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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