Nlrp4 NLR family, pyrin domain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nlrp4provided by RGD
Full Name: NLR family, pyrin domain containing 4provided by RGD
Primary source: RGD:1563529
See related: EnsemblRapid:ENSRNOG00000021996 AllianceGenome:RGD:1563529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nalp4; Nlrp4e; RGD1563529; RGD1564841
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of innate immune response and regulation of inflammatory response. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 33.9) See more
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Genomic context

Location:: 1q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (77118192..77162688, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (68089321..68132429, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (71671575..71715241, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo.
Title: NLRP4 is an essential negative regulator of fructose-induced cardiac injury in vitro and in vivo.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Rat95 (e-PCR), detects polymorphism
- UniSTS:227282

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NLR family, pyrin domain containing 4

Names: NACHT, leucine rich repeat and PYD containing 4; NLR family, pyrin domain containing 4E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172164.2 → NP_001165635.2 NLR family, pyrin domain containing 4

See identical proteins and their annotated locations for NP_001165635.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZP31

Related

ENSRNOP00000046459.6, ENSRNOT00000046152.7

Conserved Domains (7) summary

cd08320
Location:10 → 92

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:666 → 691

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:148 → 317

NACHT; NACHT domain

pfam17776
Location:451 → 564

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:393 → 449

NOD2_WH; NOD2 winged helix domain

cl39015
Location:689 → 953

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

77118192..77162688 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228201.5 → XP_006228263.1 NLR family, pyrin domain containing 4 isoform X1

See identical proteins and their annotated locations for XP_006228263.1

UniProtKB/TrEMBL

D3ZP31

Conserved Domains (7) summary

cd08320
Location:10 → 92

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:666 → 691

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:148 → 317

NACHT; NACHT domain

pfam17776
Location:451 → 564

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:393 → 449

NOD2_WH; NOD2 winged helix domain

cl39015
Location:689 → 953

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006228200.5 → XP_006228262.1 NLR family, pyrin domain containing 4 isoform X1

See identical proteins and their annotated locations for XP_006228262.1

UniProtKB/TrEMBL

D3ZP31

Conserved Domains (7) summary

cd08320
Location:10 → 92

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:666 → 691

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:148 → 317

NACHT; NACHT domain

pfam17776
Location:451 → 564

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:393 → 449

NOD2_WH; NOD2 winged helix domain

cl39015
Location:689 → 953

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039086996.1 → XP_038942924.1 NLR family, pyrin domain containing 4 isoform X1

UniProtKB/TrEMBL

D3ZP31

Conserved Domains (7) summary

cd08320
Location:10 → 92

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:891 → 918

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:666 → 691

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:148 → 317

NACHT; NACHT domain

pfam17776
Location:451 → 564

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:393 → 449

NOD2_WH; NOD2 winged helix domain

cl39015
Location:689 → 953

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...