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    Itln1 intelectin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498284, updated on 2-Nov-2024

    Summary

    Official Symbol
    Itln1provided by RGD
    Official Full Name
    intelectin 1provided by RGD
    Primary source
    RGD:1561048
    See related
    EnsemblRapid:ENSRNOG00000004678 AllianceGenome:RGD:1561048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Predicted to be involved in several processes, including positive regulation of D-glucose import; protein homotrimerization; and response to nematode. Predicted to be located in brush border membrane and membrane raft. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Orthologous to several human genes including ITLN1 (intelectin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 9.0), Liver (RPKM 1.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Itln1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86464641..86490655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83932234..83958243)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89919570..89929774)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene prothymosin alpha like 5 Neighboring gene U5 spliceosomal RNA Neighboring gene macrophage migration inhibitory factor, pseudogene 9 Neighboring gene natural killer cell receptor 2B4-like Neighboring gene 60S ribosomal protein L31 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC124684

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nematode ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    intelectin-1
    Names
    intelectin 1 (galactofuranose binding)
    intelectin 1 (galactofuranose binding)-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034946.1NP_001030118.1  intelectin-1 precursor

      See identical proteins and their annotated locations for NP_001030118.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099766
      UniProtKB/TrEMBL
      E9PT30, Q499T8
      Related
      ENSRNOP00000006196.4, ENSRNOT00000006196.6
      Conserved Domains (1) summary
      cl00085
      Location:3782
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86464641..86490655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272546.1XP_063128616.1  intelectin-1 isoform X1

    2. XM_017598901.3XP_017454390.1  intelectin-1 isoform X1

      UniProtKB/TrEMBL
      A6JG02
      Related
      ENSRNOP00000099961.1, ENSRNOT00000154691.1
    3. XM_039090984.2XP_038946912.1  intelectin-1 isoform X2