Endov endonuclease V [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Endovprovided by RGD
Official Full Name: endonuclease Vprovided by RGD
Primary source: RGD:1562414
See related: EnsemblRapid:ENSRNOG00000003699 AllianceGenome:RGD:1562414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; magnesium ion binding activity; and nucleic acid binding activity. Predicted to be involved in DNA repair. Predicted to be located in cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ENDOV (endonuclease V). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 77.9), Thymus (RPKM 38.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (105258540..105276209)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (104760059..104777732)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (108630723..108646679)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity, producing 5'-phosphomonoesters	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity, producing 5'-phosphomonoesters	ISO Inferred from Sequence Orthology more info
NOT enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters	ISO Inferred from Sequence Orthology more info
enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endonuclease V

NP_001388992.1

EC 3.1.-.-

XP_056840658.1

EC 3.1.-.-

XP_056840659.1

EC 3.1.-.-

XP_056840660.1

EC 3.1.-.-

XP_063125741.1

EC 3.1.-.-

XP_063125742.1

EC 3.1.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.