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    Rmi2 RecQ mediated genome instability 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497856, updated on 17-Aug-2024

    Summary

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    Symbol
    Rmi2provided by RGD
    Full Name
    RecQ mediated genome instability 2provided by RGD
    Primary source
    RGD:1563163
    See related
    EnsemblRapid:ENSRNOG00000065770 AllianceGenome:RGD:1563163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563163
    Summary
    Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and regulation of sister chromatid segregation. Predicted to be active in cytosol and nuclear speck. Orthologous to human RMI2 (RecQ mediated genome instability 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 57.5), Spleen (RPKM 16.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rmi2 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (5336269..5344202, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4829333..4837264, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4904458..4910339, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10, pseudogene 2 Neighboring gene lipopolysaccharide-induced TNF factor Neighboring gene uncharacterized LOC102552269 Neighboring gene protamine 1 Neighboring gene protamine 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome. Hudson DF, et al. PLoS Genet, 2016 Dec. PMID 27977684, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of rDNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of DNA recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RecQ family helicase-topoisomerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RecQ mediated genome instability 2; recQ-mediated genome instability protein 2
    Names
    RMI2, RecQ mediated genome instability 2, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430243.1 → NP_001417172.1  RecQ mediated genome instability 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      5336269..5344202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_573037.6 → XP_573037.1  recQ-mediated genome instability protein 2

      Related
      ENSRNOP00000084849.1, ENSRNOT00000095584.2
      Conserved Domains (1) summary
      pfam16100
      Location:26 → 143
      RMI2; RecQ-mediated genome instability protein 2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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