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    DLK1 delta like non-canonical Notch ligand 1 [ Sus scrofa (pig) ]

    Gene ID: 497066, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DLK1provided by VGNC
    Official Full Name
    delta like non-canonical Notch ligand 1provided by VGNC
    Primary source
    VGNC:VGNC:87333
    See related
    Ensembl:ENSSSCG00000035805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    Pref-1
    Expression
    Broad expression in longissimus dorsi muscle (RPKM 4.4), psoas major muscle (RPKM 4.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See DLK1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (121565844..121577493)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (132339547..132345907)

    Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene WD repeat domain 25 Neighboring gene hypoxanthine-guanine phosphoribosyltransferase pseudogene Neighboring gene brain enriched guanylate kinase associated Neighboring gene maternally expressed 3 Neighboring gene microRNA mir-493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs. Kim KS, et al. Mamm Genome, 2004 Jul. PMID 15366375
    2. Expression of DLK1 splice variants during porcine adipocyte development in vitro and in vivo. Samulin J, et al. Anim Genet, 2009 Apr. PMID 19032696
    3. Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells. Lahbib-Mansais Y, et al. BMC Cell Biol, 2016 Oct 1. PMID 27716032, Free PMC Article
    4. Frequency of DLK1 c.639C>T polymorphism and the analysis of MEG3/DLK1/PEG11 cluster expression in muscle of swine raised in Poland. Oczkowicz M, et al. Meat Sci, 2011 Aug. PMID 21414727
    5. Alternative splicing of delta-like 1 homolog (DLK1) in the pig and human. Deiuliis JA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2006 Sep. PMID 16901742

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
      Title: Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells.
    2. We did not observe significantly different expression of DLK1, MEG3 or PEG11 mRNA in any of analyzed breeds.
      Title: Frequency of DLK1 c.639C>T polymorphism and the analysis of MEG3/DLK1/PEG11 cluster expression in muscle of swine raised in Poland.
    3. QUASEP supports paternal expression of DLK1 in whole brain, carcass, liver and placental tissues of day 30 interbreed porcine fetuses.
      Title: Characterization of conserved and nonconserved imprinted genes in swine.
    4. Expression of DLK1 splice variants during adipocyte development in vitro and in vivo.
      Title: Expression of DLK1 splice variants during porcine adipocyte development in vitro and in vivo.
    5. Polymorphisms, imprinting status and quantitative trait locus analyses of the porcine DLK1 and MEG3 genes i swine.
      Title: Molecular characteristics of the porcine DLK1 and MEG3 genes.
    6. the sequence of porcine DLK1 (pDLK1)was examined,the expression and alternative splicing isoforms in the pig (Sus scrofa) was compared with human
      Title: Alternative splicing of delta-like 1 homolog (DLK1) in the pig and human.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein delta homolog 1
    Names
    delta-like 1 homolog
    delta-like 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048187.1 → NP_001041652.1  protein delta homolog 1 isoform B precursor

      See identical proteins and their annotated locations for NP_001041652.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ309459
      UniProtKB/TrEMBL
      A0A8D0V6K3, Q0H2C7
      Related
      ENSSSCP00000043352.2, ENSSSCT00000038148.2
      Conserved Domains (1) summary
      cd00054
      Location:88 → 125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. NM_001126101.2 → NP_001119573.1  protein delta homolog 1 isoform C2 precursor

      See identical proteins and their annotated locations for NP_001119573.1

      Status: PROVISIONAL

      Source sequence(s)
      EU597631
      UniProtKB/TrEMBL
      A0A4X1TJD1, B2LYU1, Q0H2C8
      Conserved Domains (1) summary
      cd00054
      Location:88 → 125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

      Range
      121565844..121577493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021098342.1 → XP_020954001.1  protein delta homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A287AVP6, A0A4X1TNY9, A0A8D0ZVL7, C1IEE5
      Related
      ENSSSCP00000047984.2, ENSSSCT00000048340.2
      Conserved Domains (1) summary
      cd00054
      Location:88 → 125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. XM_021098343.1 → XP_020954002.1  protein delta homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A4X1TJD1, Q0H2C8
      Conserved Domains (1) summary
      cd00054
      Location:88 → 125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. XM_021098344.1 → XP_020954003.1  protein delta homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TJD1, Q0H2C8
      Conserved Domains (1) summary
      cd00054
      Location:88 → 125
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein
    Heading Accession and Version

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