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    ODF2 outer dense fiber of sperm tails 2 [ Homo sapiens (human) ]

    Gene ID: 4957, updated on 2-Nov-2024

    Summary

    Official Symbol
    ODF2provided by HGNC
    Official Full Name
    outer dense fiber of sperm tails 2provided by HGNC
    Primary source
    HGNC:HGNC:8114
    See related
    Ensembl:ENSG00000136811 MIM:602015; AllianceGenome:HGNC:8114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT134; ODF84; ODF2/1; ODF2/2
    Summary
    The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
    Expression
    Biased expression in testis (RPKM 95.4), lymph node (RPKM 8.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
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    Genomic context

    See ODF2 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128455185..128501292)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140662221..140708139)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131217464..131263571)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29081 Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131200897-131201070 Neighboring gene protein PAT1 homolog 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131217358-131218094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131218095-131218830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131218831-131219566 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:131219567-131220302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131234689-131235190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131235191-131235690 Neighboring gene ODF2 antisense RNA 1 Neighboring gene uncharacterized LOC124902281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131257065-131257565 Neighboring gene Sharpr-MPRA regulatory region 9551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29084 Neighboring gene GLE1 RNA export mediator Neighboring gene uncharacterized LOC101929270 Neighboring gene RNA, U7 small nuclear 171 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC9034, FLJ44866, MGC111096

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole-centriole cohesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cilium organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of centriolar subdistal appendage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sperm principal piece ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    outer dense fiber protein 2
    Names
    cancer/testis antigen 134
    cenexin 1
    outer dense fiber of sperm tails, 84-kD
    sperm tail structural protein
    testis tissue sperm-binding protein Li 51e

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029568.2 RefSeqGene

      Range
      5823..51109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242352.2NP_001229281.1  outer dense fiber protein 2 isoform 11

      See identical proteins and their annotated locations for NP_001229281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses two alternate splice sites in the 5' coding region, compared to variant 1. The resulting isoform (11) has a shorter N-terminus and contains an additional internal segment compared to isoform 1.
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56590.1
      UniProtKB/Swiss-Prot
      Q5BJF6
      Related
      ENSP00000361893.5, ENST00000372807.10
      Conserved Domains (1) summary
      cl25732
      Location:114798
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001242353.2NP_001229282.1  outer dense fiber protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001229282.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) contains an alternate exon, lacks an exon and uses an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56588.1
      UniProtKB/Swiss-Prot
      B1AND3, B4DRK4, B4DX73, B4DZ02, E7EWL2, F5H6J4, O14721, O60631, Q1W2J6, Q5BJF6, Q6UN26, Q7Z5I6, Q96FN2
      Related
      ENSP00000473949.2, ENST00000604420.5
      Conserved Domains (1) summary
      COG1196
      Location:119803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. NM_001242354.2NP_001229283.1  outer dense fiber protein 2 isoform 8

      See identical proteins and their annotated locations for NP_001229283.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' coding region, lacks an alternate in-frame exon, and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (8) is shorter at the N-terminus, lacks an alternate internal segment, and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56589.1
      UniProtKB/TrEMBL
      B4DUU0
      Related
      ENSP00000396687.2, ENST00000448249.8
      Conserved Domains (1) summary
      cl25732
      Location:165485
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001351577.1NP_001338506.1  outer dense fiber protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AI478559, AL043836, AL445287, BE263555, BM824222, BQ896996, CN368207, DB094573, DC295950, HY281035
      Conserved Domains (1) summary
      cl25732
      Location:202930
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001351578.2NP_001338507.1  outer dense fiber protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS94498.1
      UniProtKB/TrEMBL
      A0A8J8YVX4
      Related
      ENSP00000342581.4, ENST00000351030.8
      Conserved Domains (1) summary
      cl25732
      Location:202886
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001351579.2NP_001338508.1  outer dense fiber protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Conserved Domains (1) summary
      cl25732
      Location:241561
      SMC_N; RecF/RecN/SMC N terminal domain
    7. NM_001351580.2NP_001338509.1  outer dense fiber protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Conserved Domains (1) summary
      cl25732
      Location:241561
      SMC_N; RecF/RecN/SMC N terminal domain
    8. NM_001351581.1NP_001338510.1  outer dense fiber protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AI478559, AK299303, AL445287, DB094573
      Conserved Domains (1) summary
      cl25732
      Location:163847
      SMC_N; RecF/RecN/SMC N terminal domain
    9. NM_001351582.2NP_001338511.1  outer dense fiber protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Conserved Domains (1) summary
      COG1196
      Location:158842
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    10. NM_001351583.2NP_001338512.1  outer dense fiber protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Conserved Domains (1) summary
      cl25732
      Location:222542
      SMC_N; RecF/RecN/SMC N terminal domain
    11. NM_001351584.2NP_001338513.1  outer dense fiber protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56590.1
      Conserved Domains (1) summary
      cl25732
      Location:114798
      SMC_N; RecF/RecN/SMC N terminal domain
    12. NM_001351585.2NP_001338514.1  outer dense fiber protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56590.1
      Conserved Domains (1) summary
      cl25732
      Location:114798
      SMC_N; RecF/RecN/SMC N terminal domain
    13. NM_001351586.2NP_001338515.1  outer dense fiber protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      UniProtKB/TrEMBL
      A0A024R8A5
      Conserved Domains (1) summary
      COG1196
      Location:95779
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    14. NM_001351587.2NP_001338516.1  outer dense fiber protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Conserved Domains (1) summary
      cl25732
      Location:111745
      SMC_N; RecF/RecN/SMC N terminal domain
    15. NM_001351588.2NP_001338517.1  outer dense fiber protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL359091, AL445287
      Conserved Domains (1) summary
      cl25732
      Location:92726
      SMC_N; RecF/RecN/SMC N terminal domain
    16. NM_002540.5NP_002531.3  outer dense fiber protein 2 isoform 9

      See identical proteins and their annotated locations for NP_002531.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains two alternate exons in the 5' coding region, compared to variant 1. The resulting isoform (9) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL359091, AL445287
      UniProtKB/TrEMBL
      A0A024R8A5
      Conserved Domains (1) summary
      COG1196
      Location:95779
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    17. NM_153432.1NP_702910.1  outer dense fiber protein 2 isoform 3

      See identical proteins and their annotated locations for NP_702910.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK093367, AL359091, DB094573, DB511337
      Consensus CDS
      CCDS56586.1
      UniProtKB/TrEMBL
      B4DX03
      Related
      ENSP00000361901.3, ENST00000372814.7
      Conserved Domains (1) summary
      COG1196
      Location:290627
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    18. NM_153433.2NP_702911.1  outer dense fiber protein 2 isoform 2

      See identical proteins and their annotated locations for NP_702911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple 5' coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56588.1
      UniProtKB/Swiss-Prot
      B1AND3, B4DRK4, B4DX73, B4DZ02, E7EWL2, F5H6J4, O14721, O60631, Q1W2J6, Q5BJF6, Q6UN26, Q7Z5I6, Q96FN2
      Related
      ENSP00000403453.2, ENST00000434106.7
      Conserved Domains (1) summary
      COG1196
      Location:119803
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    19. NM_153435.1NP_702913.1  outer dense fiber protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL445287, AY366499, DB094573
      Consensus CDS
      CCDS94497.1
      UniProtKB/TrEMBL
      A0A8J8Z1C3
      Related
      ENSP00000377161.6, ENST00000393527.8
      Conserved Domains (1) summary
      pfam00038
      Location:529857
      Filament; Intermediate filament protein
    20. NM_153436.2NP_702914.1  outer dense fiber protein 2 isoform 4

      See identical proteins and their annotated locations for NP_702914.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 4) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56585.1
      UniProtKB/TrEMBL
      B4DX85
      Related
      ENSP00000377166.2, ENST00000393533.6
      Conserved Domains (2) summary
      COG1196
      Location:246566
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:104384
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    21. NM_153437.3NP_702915.1  outer dense fiber protein 2 isoform 6

      See identical proteins and their annotated locations for NP_702915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 6) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS6902.1
      UniProtKB/TrEMBL
      B4DX85
      Related
      ENSP00000361877.3, ENST00000372791.8
      Conserved Domains (2) summary
      COG1196
      Location:227547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:85365
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    22. NM_153439.1NP_702917.1  outer dense fiber protein 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK301754, AL359091, DB094573, DB511337
      UniProtKB/TrEMBL
      B4DX03
      Conserved Domains (2) summary
      COG1196
      Location:271606
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:129409
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    23. NM_153440.2NP_702918.1  outer dense fiber protein 2 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 7) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AL359091, AL445287
      Consensus CDS
      CCDS56587.1
      UniProtKB/TrEMBL
      B4DX85
      Related
      ENSP00000437579.1, ENST00000546203.5
      Conserved Domains (2) summary
      COG1196
      Location:227547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:85365
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      128455185..128501292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      140662221..140708139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)