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    SIRPA signal regulatory protein alpha [ Sus scrofa (pig) ]

    Gene ID: 494566, updated on 5-Mar-2024

    Summary

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    Gene symbol
    SIRPA
    Gene description
    signal regulatory protein alpha
    See related
    Ensembl:ENSSSCG00000028461
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    swc3; CD172; PTPNS1
    Expression
    Broad expression in spleen (RPKM 60.6), lung (RPKM 17.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See SIRPA in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (33566270..33611375, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (37961460..37968581, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003540434.1 (3260..19631)

    Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 35 Neighboring gene prodynorphin Neighboring gene uncharacterized LOC102161572 Neighboring gene tyrosine-protein phosphatase non-receptor type substrate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning characterization and expression of porcine immunoreceptor SIRPalpha. Alvarez B, et al. Dev Comp Immunol, 2007. PMID 16911825
    2. A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Alvarez B, et al. Tissue Antigens, 2000 Apr. PMID 10852386
    3. Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions. Moralez AM, et al. J Cell Physiol, 2005 May. PMID 15700281
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    protein tyrosine phosphatase, non-receptor type substrate 1
    swine workshop cluster 3 antigen
    NP_001011508.1
    XP_020932980.1
    XP_020932981.1
    XP_020932982.1
    XP_020932983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011508.2 → NP_001011508.1  tyrosine-protein phosphatase non-receptor type substrate 1 precursor

      See identical proteins and their annotated locations for NP_001011508.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ544724
      UniProtKB/TrEMBL
      A0A8D1Q9Y8, I3LAN1, Q5K4Q3
      Conserved Domains (3) summary
      cd05772
      Location:150 → 253
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:255 → 357
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 147
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

      Range
      33566270..33611375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021077321.1 → XP_020932980.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D1TZN5, F1S887
      Related
      ENSSSCP00000007645.5, ENSSSCT00000007856.5
      Conserved Domains (3) summary
      cd05772
      Location:150 → 253
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:255 → 357
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 147
      Ig; Immunoglobulin domain

    2. XM_021077323.1 → XP_020932982.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      A0A8D1Q9Y8, I3LAN1, Q5K4Q3
      Conserved Domains (3) summary
      cd05772
      Location:150 → 253
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:255 → 357
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 147
      Ig; Immunoglobulin domain

    3. XM_021077322.1 → XP_020932981.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D1TZN5, F1S887
      Conserved Domains (3) summary
      cd05772
      Location:150 → 253
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:255 → 357
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 147
      Ig; Immunoglobulin domain

    4. XM_021077324.1 → XP_020932983.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/TrEMBL
      A0A8D1Q9Y8, I3LAN1, Q5K4Q3
      Related
      ENSSSCP00000029685.4, ENSSSCT00000036670.4
      Conserved Domains (3) summary
      cd05772
      Location:150 → 253
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:255 → 357
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35 → 147
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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