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    slc6a5 solute carrier family 6 member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 494450, updated on 2-Nov-2024

    Summary

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    Official Symbol
    slc6a5provided by ZNC
    Official Full Name
    solute carrier family 6 member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050105-2
    See related
    Ensembl:ENSDARG00000067964 AllianceGenome:ZFIN:ZDB-GENE-050105-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    glyt2; si:dkey-7n10.12
    Summary
    Predicted to enable glycine:sodium symporter activity. Predicted to be involved in glycine import across plasma membrane; glycinergic synaptic transmission; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system and glycinergic neurons. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc6a5 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (17229282..17252103)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (16974960..16995846)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene HIV-1 Tat interactive protein 2 Neighboring gene protein arginine methyltransferase 3 Neighboring gene si:ch73-266m14.1 Neighboring gene novel immune-type receptor 12 Neighboring gene novel immune-type receptor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Na+/K+-ATPase is a new interacting partner for the neuronal glycine transporter GlyT2 that downregulates its expression in vitro and in vivo. de Juan-Sanz J, et al. J Neurosci, 2013 Aug 28. PMID 23986260, Free PMC Article
    2. A topographic map of recruitment in spinal cord. McLean DL, et al. Nature, 2007 Mar 1. PMID 17330042
    3. Distribution of glycinergic neurons in the brain of glycine transporter-2 transgenic Tg(glyt2:Gfp) adult zebrafish: relationship to brain-spinal descending systems. Barreiro-Iglesias A, et al. J Comp Neurol, 2013 Feb 1. PMID 22736487
    4. Identification of initially appearing glycine-immunoreactive neurons in the embryonic zebrafish brain. Moly PK, et al. Dev Neurobiol, 2014 Jun. PMID 24318965
    5. The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS. Cui WW, et al. J Neurosci, 2005 Jul 13. PMID 16014722, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
      Title: The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.
    2. A few groups of GLYT2(-) cells were observed in the midbrain and forebrain, including numerous pinealocytes
      Title: Distribution of glycinergic neurons in the brain of glycine transporter-2 transgenic Tg(glyt2:Gfp) adult zebrafish: relationship to brain-spinal descending systems.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glycine:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glycinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium- and chloride-dependent glycine transporter 2
    Names
    glycine transporter 2
    solute carrier family 6 (neurotransmitter transporter), member 5
    solute carrier family 6 (neurotransmitter transporter, glycine), member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009557.1 → NP_001009557.1  sodium- and chloride-dependent glycine transporter 2

      See identical proteins and their annotated locations for NP_001009557.1

      Status: PROVISIONAL

      Source sequence(s)
      AB183389
      UniProtKB/TrEMBL
      B3DFM7, K7DXY4, Q5W8I5
      Related
      ENSDARP00000088755.4, ENSDART00000097982.6
      Conserved Domains (1) summary
      cl00456
      Location:177 → 775
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      17229282..17252103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302965.4 → XP_009301240.1  sodium- and chloride-dependent glycine transporter 2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q8E9, A0A8M3B0Z1
      Related
      ENSDARP00000147557.1, ENSDART00000184910.1
      Conserved Domains (1) summary
      cl00456
      Location:169 → 767
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394681.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      4188..22725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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