CA3 carbonic anhydrase 3 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CA3provided by VGNC
Official Full Name: carbonic anhydrase 3provided by VGNC
Primary source: VGNC:VGNC:86099
See related: Ensembl:ENSSSCG00000006141
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in longissimus dorsi muscle (RPKM 1279.3), psoas major muscle (RPKM 820.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (51227485..51237861, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (56190405..56200779, complement)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrated that CA-III is bound to the transferrin and albumin, and that its levels were higher in diseased swine compared with the healthy pigs.
Title: Purification of swine carbonic anhydrase isoenzyme III and measurement of its levels in tissues and plasma.
The temporal and spatial distributions of CA3 gene product were analysed and the association between the presence of specific polymorphisms and carcass traits in the pig was also examined.
Title: Expression pattern and polymorphism of three microsatellite markers in the porcine CA3 gene.
Molecular characterization revealed that CA3 genomic DNA consists of seven exons and six introns, spans about 10.5 kb and maps to porcine chromosome 4q11-->q14.
Title: Molecular characterization and association analysis of porcine CA3.

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General gene information

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Markers

Car3 (e-PCR), detects polymorphism
- UniSTS:255279

CA3 (e-PCR)
- UniSTS:504294

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: carbonic anhydrase 3

Names: CA-III; carbonate dehydratase III; carbonic anhydrase III, muscle specific

NP_001008688.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008688.1 → NP_001008688.1 carbonic anhydrase 3

See identical proteins and their annotated locations for NP_001008688.1

Status: PROVISIONAL

Source sequence(s)

AY789645

UniProtKB/Swiss-Prot

Q0Z809, Q5S1S4

UniProtKB/TrEMBL

A0A5S6G0V8, A0A8D1TUD9

Related

ENSSSCP00000006551.4, ENSSSCT00000006734.5

Conserved Domains (1) summary

cd03119
Location:1 → 259

alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...