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    KITLG KIT ligand [ Felis catus (domestic cat) ]

    Gene ID: 493937, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KITLG
    Official Full Name
    KIT ligand
    Primary source
    VGNC:VGNC:84045
    See related
    EnsemblRapid:ENSFCTG00005011476
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Also known as
    SCF
    Orthologs
    human mouse all
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    Genomic context

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    See KITLG in Genome Data Viewer
    Location:
    chromosome: B4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (110717747..110818253, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (112958775..113038428, complement)

    Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123386670 Neighboring gene ras-related C3 botulinum toxin substrate 1-like Neighboring gene uncharacterized LOC123386671 Neighboring gene uncharacterized LOC123386669 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC123386668

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of Stem Cell Factor in Feline Mast Cell Tumour. Sakurai M, et al. J Comp Pathol, 2018 Aug. PMID 30213375
    2. Stem cell factor promotes in vitro ovarian follicle development in the domestic cat by upregulating c-kit mRNA expression and stimulating the phosphatidylinositol 3-kinase/AKT pathway. Thuwanut P, et al. Reprod Fertil Dev, 2017 Jul. PMID 27279472
    3. The cloning and sequencing of cDNAs encoding two isoforms of feline stem cell factor. Dunham SP, et al. DNA Seq, 1996. PMID 8912926

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables stem cell factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kit ligand
    Names
    C-kit ligand
    MGF
    mast cell growth factor
    stem cell factor
    NP_001009343.1
    XP_044916692.1
    XP_044916693.1
    XP_044916694.1
    XP_044916695.1
    XP_044916696.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009343.1 → NP_001009343.1  kit ligand precursor

      See identical proteins and their annotated locations for NP_001009343.1

      Status: PROVISIONAL

      Source sequence(s)
      D50833
      UniProtKB/Swiss-Prot
      P79169
      UniProtKB/TrEMBL
      A0A5F5Y1Y4
      Related
      ENSFCTP00005021606.1, ENSFCTT00005032426.1
      Conserved Domains (1) summary
      pfam02404
      Location:1 → 274
      SCF; Stem cell factor

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      110717747..110818253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045060759.1 → XP_044916694.1  kit ligand isoform X2

    2. XM_045060760.1 → XP_044916695.1  kit ligand isoform X3

    3. XM_045060758.1 → XP_044916693.1  kit ligand isoform X1

    4. XM_045060757.1 → XP_044916692.1  kit ligand isoform X1

      Related
      ENSFCTP00005021560.1, ENSFCTT00005032374.1

    5. XM_045060761.1 → XP_044916696.1  kit ligand isoform X4

      UniProtKB/TrEMBL
      A0A5F5Y1Y4
      Related
      ENSFCTP00005021458.1, ENSFCTT00005032264.1
      Conserved Domains (1) summary
      pfam02404
      Location:9 → 277
      SCF; Stem cell factor

    RNA

    1. XR_006600173.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79169.1 GenPept UniProtKB/Swiss-Prot:P79169

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials