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    GAD1 glutamate decarboxylase 1 [ Felis catus (domestic cat) ]

    Gene ID: 493699, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GAD1
    Official Full Name
    glutamate decarboxylase 1
    Primary source
    VGNC:VGNC:62430
    See related
    EnsemblRapid:ENSFCTG00005017990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Also known as
    GAD67
    Orthologs
    human mouse all
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    Genomic context

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    See GAD1 in Genome Data Viewer
    Location:
    chromosome: C1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C1 NC_058375.1 (159447430..159490141)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C1 NC_018730.3 (162083872..162126348)

    Chromosome C1 - NC_058375.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109502724 Neighboring gene glutamate rich 2 Neighboring gene uncharacterized LOC123379169 Neighboring gene uncharacterized LOC109502725 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-localization of glutamic acid decarboxylase and phosphate-activated glutaminase in neurons of lateral reticular nucleus in feline thalamus. Fisher RS. Neurochem Res, 2007 Feb. PMID 16927169
    2. Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein. Kobayashi Y, et al. J Neurosci, 1987 Sep. PMID 3453123, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. glutamic acid decarboxylase- and glutaminase-immunoreactivity exhibited matching regional patterns of organization within lateral reticular nucleus neurons.
      Title: Co-localization of glutamic acid decarboxylase and phosphate-activated glutaminase in neurons of lateral reticular nucleus in feline thalamus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate decarboxylase 1
    Names
    67 kDa glutamic acid decarboxylase
    GAD-67
    glutamic acid decarboxylase
    NP_001009225.1
    XP_019691504.2
    XP_019691505.2
    XP_019691506.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009225.1 → NP_001009225.1  glutamate decarboxylase 1

      See identical proteins and their annotated locations for NP_001009225.1

      Status: PROVISIONAL

      Source sequence(s)
      M18629
      UniProtKB/Swiss-Prot
      P14748
      UniProtKB/TrEMBL
      A0A5F5XSK7
      Conserved Domains (1) summary
      pfam00282
      Location:144 → 518
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058375.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      159447430..159490141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_019835946.3 → XP_019691505.2  glutamate decarboxylase 1 isoform X2

      UniProtKB/Swiss-Prot
      P14748
      UniProtKB/TrEMBL
      A0A5F5XSK7
      Conserved Domains (1) summary
      pfam00282
      Location:144 → 518
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    2. XM_019835947.3 → XP_019691506.2  glutamate decarboxylase 1 isoform X2

      UniProtKB/Swiss-Prot
      P14748
      UniProtKB/TrEMBL
      A0A5F5XSK7
      Related
      ENSFCTP00005038433.1, ENSFCTT00005052404.1
      Conserved Domains (1) summary
      pfam00282
      Location:144 → 518
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    3. XM_019835945.3 → XP_019691504.2  glutamate decarboxylase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F5XSK7, M3W736
      Related
      ENSFCTP00005038017.1, ENSFCTT00005051884.1
      Conserved Domains (1) summary
      pfam00282
      Location:154 → 528
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14748.3 GenPept UniProtKB/Swiss-Prot:P14748

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials