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    TLR4 toll like receptor 4 [ Felis catus (domestic cat) ]

    Gene ID: 493698, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLR4
    Official Full Name
    toll like receptor 4
    Primary source
    VGNC:VGNC:66220
    See related
    EnsemblRapid:ENSFCTG00005010189
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See TLR4 in Genome Data Viewer
    Location:
    chromosome: D4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) D4 NC_058380.1 (77141716..77155989)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) D4 NC_018735.3 (79270745..79281675)

    Chromosome D4 - NC_058380.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain-like Neighboring gene astrotactin 2 Neighboring gene uncharacterized LOC123381696 Neighboring gene tripartite motif containing 32 Neighboring gene uncharacterized LOC123381807 Neighboring gene uncharacterized LOC123381552 Neighboring gene uncharacterized LOC109493635 Neighboring gene uncharacterized LOC123381539 Neighboring gene uncharacterized LOC109493636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Breed-specific variations in the coding region of toll-like receptor 4 in the domestic cat. Whitney J, et al. Vet Immunol Immunopathol, 2019 Mar. PMID 30885307, Free PMC Article
    2. Overexpression of TLR-2 and TLR-4 mRNA in feline polymorphonuclear neutrophils exposed to Microsporum canis. Cambier LC, et al. Vet Dermatol, 2016 Apr. PMID 26914839
    3. The role of toll-like receptors 2 and 4 in the pathogenesis of feline pyometra. Jursza E, et al. Theriogenology, 2015 Mar 1. PMID 25481489
    4. Feline serum amyloid A protein as an endogenous Toll-like receptor 4 agonist. Tamamoto T, et al. Vet Immunol Immunopathol, 2013 Sep 15. PMID 23942262
    5. Full-length cDNA cloning of Toll-like receptor 4 in dogs and cats. Asahina Y, et al. Vet Immunol Immunopathol, 2003 Dec 15. PMID 14592729

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. No associations between polymorphisms in the coding sequences of TL1, TLR2 or TLR4 and the development of feline upper respiratory tract aspergillosis were identified.
      Title: Genetic polymorphisms in toll-like receptors 1, 2, and 4 in feline upper respiratory tract aspergillosis.
    2. polymorphisms in feline TLR4 and their effect on protein structure and predicted function, which might influence disease pathogenesis
      Title: Breed-specific variations in the coding region of toll-like receptor 4 in the domestic cat.
    3. The overexpression of TLR-2 and TLR-4 mRNAs in stimulated feline PMNs suggests that these receptors are involved in the host immune response through the recognition of M. canis pathogen associated molecular patterns.
      Title: Overexpression of TLR-2 and TLR-4 mRNA in feline polymorphonuclear neutrophils exposed to Microsporum canis.
    4. These data show that short-term and especially long-term administration of progesterone derivatives impairs TLRs in the endometrial epithelium.
      Title: The role of toll-like receptors 2 and 4 in the pathogenesis of feline pyometra.
    5. Feline serum amyloid A protein as an endogenous Toll-like receptor 4 agonist.
      Title: Feline serum amyloid A protein as an endogenous Toll-like receptor 4 agonist.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopolysaccharide immune receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 4
    NP_001009223.1
    XP_019671055.1
    XP_044898385.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009223.1 → NP_001009223.1  toll-like receptor 4 precursor

      See identical proteins and their annotated locations for NP_001009223.1

      Status: PROVISIONAL

      Source sequence(s)
      AB060687
      UniProtKB/Swiss-Prot
      P58727
      UniProtKB/TrEMBL
      A0A2I2UR71
      Related
      ENSFCTP00005018558.1, ENSFCTT00005028483.1
      Conserved Domains (6) summary
      smart00255
      Location:674 → 816
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:353 → 581
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:375 → 400
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:150 → 190
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:59 → 114
      LRR_8; Leucine rich repeat
      cl15307
      Location:579 → 626
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058380.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      77141716..77155989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045042450.1 → XP_044898385.1  toll-like receptor 4 isoform X1

      Conserved Domains (3) summary
      smart00255
      Location:501 → 643
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:177 → 432
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:202 → 227
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_019815496.2 → XP_019671055.1  toll-like receptor 4 isoform X1

      Conserved Domains (3) summary
      smart00255
      Location:501 → 643
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:177 → 432
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:202 → 227
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58727.1 GenPept UniProtKB/Swiss-Prot:P58727

    Gene LinkOut

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