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    ACHE acetylcholinesterase [ Felis catus (domestic cat) ]

    Gene ID: 493674, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ACHE
    Official Full Name
    acetylcholinesterase
    Primary source
    VGNC:VGNC:80549
    See related
    EnsemblRapid:ENSFCTG00005004016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See ACHE in Genome Data Viewer
    Location:
    chromosome: E3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E3 NC_058383.1 (7891587..7898313, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) E3 NC_018738.3 (7957748..7964603, complement)

    Chromosome E3 - NC_058383.1Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene serrate, RNA effector molecule Neighboring gene UFM1 specific peptidase 1 Neighboring gene uncharacterized LOC109495140 Neighboring gene mucin-3B-like Neighboring gene mucin 3A, cell surface associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma. Bartels CF, et al. Biochem Pharmacol, 2000 Aug 15. PMID 10874122
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholinesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetylcholine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in choline metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetylcholinesterase
    Names
    acetylcholinesterase (Cartwright blood group)
    NP_001009203.1
    XP_011288624.1
    XP_019675778.1
    XP_019675779.1
    XP_019675780.1
    XP_023101968.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009203.1 → NP_001009203.1  acetylcholinesterase precursor

      See identical proteins and their annotated locations for NP_001009203.1

      Status: PROVISIONAL

      Source sequence(s)
      AF053485
      UniProtKB/Swiss-Prot
      O62762, O62763
      UniProtKB/TrEMBL
      A0A5H1ZRJ4
      Conserved Domains (3) summary
      COG0657
      Location:129 → 234
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:33 → 560
      COesterase; Carboxylesterase family
      pfam08674
      Location:575 → 608
      AChE_tetra; Acetylcholinesterase tetramerization domain

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058383.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      7891587..7898313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023246200.2 → XP_023101968.1  acetylcholinesterase isoform X2

      UniProtKB/TrEMBL
      A0A5H1ZRJ4
      Related
      ENSFCTP00005006722.1, ENSFCTT00005010798.1
      Conserved Domains (2) summary
      pfam08674
      Location:593 → 626
      AChE_tetra; Acetylcholinesterase tetramerisation domain
      pfam00135
      Location:52 → 578
      COesterase; Carboxylesterase family

    2. XM_019820219.3 → XP_019675778.1  acetylcholinesterase isoform X1

      Conserved Domains (1) summary
      pfam00135
      Location:52 → 578
      COesterase; Carboxylesterase family

    3. XM_011290322.4 → XP_011288624.1  acetylcholinesterase isoform X3

      See identical proteins and their annotated locations for XP_011288624.1

      UniProtKB/Swiss-Prot
      O62763
      Related
      ENSFCTP00005006718.1, ENSFCTT00005010792.1
      Conserved Domains (1) summary
      pfam00135
      Location:34 → 560
      COesterase; Carboxylesterase family

    4. XM_019820220.3 → XP_019675779.1  acetylcholinesterase isoform X3

      UniProtKB/Swiss-Prot
      O62763
      Conserved Domains (1) summary
      pfam00135
      Location:34 → 560
      COesterase; Carboxylesterase family

    5. XM_019820221.3 → XP_019675780.1  acetylcholinesterase isoform X3

      UniProtKB/Swiss-Prot
      O62763
      Conserved Domains (1) summary
      pfam00135
      Location:34 → 560
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62763.1 GenPept UniProtKB/Swiss-Prot:O62763

    Gene LinkOut

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