spred1 sprouty related, EVH1 domain containing 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: spred1provided by Xenbase
Official Full Name: sprouty related, EVH1 domain containing 1provided by Xenbase
Primary source: Xenbase:XB-GENE-482851
See related: Ensembl:ENSXETG00000018057
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: Xspred1; Xtspred1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (110791673..110841608, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (90501110..90551512, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spred1 and 2 inhibit MAPK activation and mesoderm specification, with little effect on Ca(2+) or PKCdelta signaling.
Title: FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation.
crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution
Title: 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sprouty-related, EVH1 domain-containing protein 1

Names: spred-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008036.1 → NP_001008037.1 sprouty-related, EVH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_001008037.1

Status: PROVISIONAL

Source sequence(s)

BC080919

UniProtKB/Swiss-Prot

Q66JG9

UniProtKB/TrEMBL

A0A803J3S4

Related

ENSXETP00000039156.5, ENSXETT00000039156.5

Conserved Domains (2) summary

cd10574
Location:10 → 122

EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

pfam05210
Location:297 → 390

Sprouty; Sprouty protein (Spry)