U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    pip5k1ab phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b [ Danio rerio (zebrafish) ]

    Gene ID: 492549, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pip5k1abprovided by ZNC
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041111-123
    See related
    Ensembl:ENSDARG00000024642 AllianceGenome:ZFIN:ZDB-GENE-041111-123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7140933; zgc:158838
    Summary
    Predicted to enable ATP binding activity and phosphatidylinositol phosphate kinase activity. Acts upstream of or within endocytosis. Is expressed in head and pronephric duct. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pip5k1ab in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (9726100..9761785)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (9835202..9867668)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100149966 Neighboring gene extracellular matrix protein 1b Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4b Neighboring gene vesicle associated membrane protein 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Apical PtdIns(4,5)P(2) is required for ciliogenesis and suppression of polycystic kidney disease. Xu W, et al. FASEB J, 2019 Feb. PMID 30321068
    2. The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule. Oltrabella F, et al. PLoS Genet, 2015 Apr. PMID 25838181, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
    NP_001082822.1
    XP_021322354.1
    XP_068070050.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089353.1 → NP_001082822.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

      See identical proteins and their annotated locations for NP_001082822.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129481
      UniProtKB/TrEMBL
      A2VD51
      Related
      ENSDARP00000014071.7, ENSDART00000020859.10
      Conserved Domains (1) summary
      smart00330
      Location:84 → 430
      PIPKc; Phosphatidylinositol phosphate kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      9726100..9761785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213949.1 → XP_068070050.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

    2. XM_021466679.2 → XP_021322354.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M9PD30
      Related
      ENSDARP00000153838.1, ENSDART00000192988.1
      Conserved Domains (1) summary
      smart00330
      Location:98 → 444
      PIPKc; Phosphatidylinositol phosphate kinases
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools