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    LCN2 lipocalin 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 491320, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LCN2provided by VGNC
    Official Full Name
    lipocalin 2provided by VGNC
    Primary source
    VGNC:VGNC:42612
    See related
    Ensembl:ENSCAFG00845029755
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See LCN2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (56250316..56264670, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (54522898..54537231, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (55416588..55430934, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (55010191..55024522, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (55324906..55339237, complement)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene dynamin 1 Neighboring gene microRNA mir-199-3 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein Neighboring gene 60S ribosomal protein L30-like Neighboring gene prostaglandin E synthase 2 Neighboring gene solute carrier family 25 member 25 Neighboring gene uncharacterized LOC119873364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity. Palm CA, et al. J Vet Intern Med, 2016 Jan-Feb. PMID 26725776, Free PMC Article
    2. Neutrophil Gelatinase-Associated Lipocalin in Dogs With Sepsis Undergoing Emergency Laparotomy: A Prospective Case-Control Study. Cortellini S, et al. J Vet Intern Med, 2015 Nov-Dec. PMID 26415728, Free PMC Article
    3. The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases. Hsu WL, et al. BMC Vet Res, 2014 Aug 27. PMID 25160665, Free PMC Article
    4. Expression and the molecular forms of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase 9 in canine mammary tumours. Chen YC, et al. Vet Comp Oncol, 2019 Sep. PMID 31050171
    5. Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells. Konno T, et al. PLoS One, 2016. PMID 27851800, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It was concluded that NGAL and MMP9 are ubiquitously expressed in canine mammary epithelial cells in normal and cancerous status; however, the NGAL/MMP9 complex exclusively presents in mammary tissues and urine of dogs with tumours.
      Title: Expression and the molecular forms of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase 9 in canine mammary tumours.
    2. the regulation of the expression and function of NGAL in IL-1beta-treated Madin-Darby canine kidney (MDCK) cells, was investigated.
      Title: Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.
    3. The urinary NGAL-to-urinary creatinine ratio was early marker of gentamicin-induced acute kidney injury and its decrease documented onset of renal recovery.
      Title: Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity.
    4. Serum neutrophil gelatinase-associated lipocalin and urinary creatinine concentration are increased in dogs with sepsis requiring emergency laparotomy.
      Title: Neutrophil Gelatinase-Associated Lipocalin in Dogs With Sepsis Undergoing Emergency Laparotomy: A Prospective Case-Control Study.
    5. This study evaluated the existence of various forms of neutrophil-associated lipocalin in urine and whether these forms were related to the different urinary diseases of dogs.
      Title: The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neutrophil gelatinase-associated lipocalin
    Names
    lipocalin 2 (oncogene 24p3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      56250316..56264670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038678463.1 → XP_038534391.1  neutrophil gelatinase-associated lipocalin isoform X2

      UniProtKB/TrEMBL
      A0A8C0KRC2
      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_038678464.1 → XP_038534392.1  neutrophil gelatinase-associated lipocalin isoform X2

      UniProtKB/TrEMBL
      A0A8C0KRC2
      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_038678462.1 → XP_038534390.1  neutrophil gelatinase-associated lipocalin isoform X1

      UniProtKB/TrEMBL
      A0A8C0KRC2, A0A8C0SRA0, A0A8I3Q9B0
      Related
      ENSCAFP00845041367.1, ENSCAFT00845052701.1
      Conserved Domains (1) summary
      cl10502
      Location:24 → 196
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      55010191..55024522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038487292.1 → XP_038343220.1  neutrophil gelatinase-associated lipocalin isoform X2

      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_038487293.1 → XP_038343221.1  neutrophil gelatinase-associated lipocalin isoform X2

      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_038487291.1 → XP_038343219.1  neutrophil gelatinase-associated lipocalin isoform X1

      Conserved Domains (1) summary
      cl10502
      Location:24 → 196
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      55324906..55339237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038613163.1 → XP_038469091.1  neutrophil gelatinase-associated lipocalin isoform X2

      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_038613164.1 → XP_038469092.1  neutrophil gelatinase-associated lipocalin isoform X2

      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_038613162.1 → XP_038469090.1  neutrophil gelatinase-associated lipocalin isoform X1

      Conserved Domains (1) summary
      cl10502
      Location:24 → 196
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      55416588..55430934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038549219.1 → XP_038405147.1  neutrophil gelatinase-associated lipocalin isoform X2

      UniProtKB/TrEMBL
      A0A8C0KRC2
      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_038549220.1 → XP_038405148.1  neutrophil gelatinase-associated lipocalin isoform X2

      UniProtKB/TrEMBL
      A0A8C0KRC2
      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_038549218.1 → XP_038405146.1  neutrophil gelatinase-associated lipocalin isoform X1

      UniProtKB/TrEMBL
      A0A8C0KRC2, A0A8C0SRA0, A0A8I3Q9B0
      Conserved Domains (1) summary
      cl10502
      Location:24 → 196
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      54522898..54537231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618381.1 → XP_038474309.1  neutrophil gelatinase-associated lipocalin isoform X2

      UniProtKB/TrEMBL
      A0A8C0KRC2
      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_038618383.1 → XP_038474311.1  neutrophil gelatinase-associated lipocalin isoform X2

      UniProtKB/TrEMBL
      A0A8C0KRC2
      Conserved Domains (1) summary
      cl10502
      Location:24 → 193
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_022423770.2 → XP_022279478.1  neutrophil gelatinase-associated lipocalin isoform X1

      UniProtKB/TrEMBL
      A0A8C0KRC2, A0A8C0SRA0, A0A8I3Q9B0
      Conserved Domains (1) summary
      cl10502
      Location:24 → 196
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
    Nucleotide Protein
    Heading Accession and Version

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