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    LIG3 DNA ligase 3 [ Canis lupus familiaris (dog) ]

    Gene ID: 491145, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LIG3provided by VGNC
    Official Full Name
    DNA ligase 3provided by VGNC
    Primary source
    VGNC:VGNC:42674
    See related
    Ensembl:ENSCAFG00845010737
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See LIG3 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (39158185..39178954, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (37569261..37590027, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (38314196..38334891, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (37940790..37961563, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (38226708..38247470, complement)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097423 Neighboring gene RAD51 paralog D Neighboring gene uncharacterized LOC119873319 Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC111097424 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair, DNA ligation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via alternative nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lagging strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase III-XRCC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 3
    XP_005624869.1
    XP_005624870.1
    XP_005624871.1
    XP_013972226.1
    XP_013972227.1
    XP_022279016.1
    XP_038342218.1
    XP_038342219.1
    XP_038342220.1
    XP_038342221.1
    XP_038342222.1
    XP_038342223.1
    XP_038404039.1
    XP_038404040.1
    XP_038404041.1
    XP_038404042.1
    XP_038404043.1
    XP_038404044.1
    XP_038468010.1
    XP_038468011.1
    XP_038468012.1
    XP_038468013.1
    XP_038468014.1
    XP_038468015.1
    XP_038533256.1
    XP_038533257.1
    XP_038533258.1
    XP_038533259.1
    XP_038533260.1
    XP_038533261.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      39158185..39178954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038677332.1 → XP_038533260.1  DNA ligase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NNS4, A0A8C0S6S7, A0A8I3N6P7
      Related
      ENSCAFP00845014795.1, ENSCAFT00845018934.1
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 805
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:889 → 960
      LIG3_BRCT; DNA ligase 3 BRCT domain

    2. XM_038677328.1 → XP_038533256.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Related
      ENSCAFP00845014831.1, ENSCAFT00845018986.1
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    3. XM_038677331.1 → XP_038533259.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    4. XM_038677330.1 → XP_038533258.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    5. XM_038677329.1 → XP_038533257.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    6. XM_038677333.1 → XP_038533261.1  DNA ligase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KJQ5, A0A8C0NXS0, A0A8C0S7L5, A0A8I3N6V9
      Related
      ENSCAFP00845014867.1, ENSCAFT00845019030.1
      Conserved Domains (2) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      37940790..37961563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038486294.1 → XP_038342222.1  DNA ligase 3 isoform X2

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 805
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:889 → 960
      LIG3_BRCT; DNA ligase 3 BRCT domain

    2. XM_038486290.1 → XP_038342218.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    3. XM_038486293.1 → XP_038342221.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    4. XM_038486292.1 → XP_038342220.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    5. XM_038486291.1 → XP_038342219.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    6. XM_038486295.1 → XP_038342223.1  DNA ligase 3 isoform X3

      Conserved Domains (2) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      38226708..38247470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038612086.1 → XP_038468014.1  DNA ligase 3 isoform X2

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 805
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:889 → 960
      LIG3_BRCT; DNA ligase 3 BRCT domain

    2. XM_038612082.1 → XP_038468010.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    3. XM_038612085.1 → XP_038468013.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    4. XM_038612084.1 → XP_038468012.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    5. XM_038612083.1 → XP_038468011.1  DNA ligase 3 isoform X1

      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    6. XM_038612087.1 → XP_038468015.1  DNA ligase 3 isoform X3

      Conserved Domains (2) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      38314196..38334891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038548115.1 → XP_038404043.1  DNA ligase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NNS4, A0A8C0S6S7, A0A8I3N6P7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 805
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:889 → 960
      LIG3_BRCT; DNA ligase 3 BRCT domain

    2. XM_038548111.1 → XP_038404039.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    3. XM_038548114.1 → XP_038404042.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    4. XM_038548113.1 → XP_038404041.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    5. XM_038548112.1 → XP_038404040.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    6. XM_038548116.1 → XP_038404044.1  DNA ligase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KJQ5, A0A8C0NXS0, A0A8C0S7L5, A0A8I3N6V9
      Conserved Domains (2) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37569261..37590027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005624813.4 → XP_005624870.1  DNA ligase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NNS4, A0A8C0S6S7, A0A8I3N6P7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 805
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:889 → 960
      LIG3_BRCT; DNA ligase 3 BRCT domain

    2. XM_005624812.4 → XP_005624869.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    3. XM_022423308.2 → XP_022279016.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    4. XM_014116752.3 → XP_013972227.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    5. XM_014116751.3 → XP_013972226.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NM77, A0A8C0NNS4, A0A8C0R0X8, A0A8I3N6S7
      Conserved Domains (3) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam16759
      Location:915 → 986
      LIG3_BRCT; DNA ligase 3 BRCT domain

    6. XM_005624814.4 → XP_005624871.1  DNA ligase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0KJQ5, A0A8C0NXS0, A0A8C0S7L5, A0A8I3N6V9
      Conserved Domains (2) summary
      TIGR00574
      Location:319 → 831
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00645
      Location:97 → 182
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
    Nucleotide Protein
    Heading Accession and Version

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