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    BRF1 BRF1 RNA polymerase III transcription initiation factor subunit [ Canis lupus familiaris (dog) ]

    Gene ID: 490883, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BRF1provided by VGNC
    Official Full Name
    BRF1 RNA polymerase III transcription initiation factor subunitprovided by VGNC
    Primary source
    VGNC:VGNC:38523
    See related
    Ensembl:ENSCAFG00845023117
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See BRF1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (72875602..72927645, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (72099839..72151572, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (72997125..73048881, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (72556286..72608091, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (72607209..72658851, complement)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene formin-like protein 5 Neighboring gene nudix hydrolase 14 Neighboring gene BTB domain containing 6 Neighboring gene uncharacterized LOC119872936 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene testis expressed 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase III general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription factor TFIIIB complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor IIIB 90 kDa subunit
    Names
    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
    zinc finger protein 36, C3H type-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      72875602..72927645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038674849.1 → XP_038530777.1  transcription factor IIIB 90 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A0A8C0K3Q3, A0A8C0MJG0, A0A8I3PEJ4
      Related
      ENSCAFP00845032218.1, ENSCAFT00845041113.1
      Conserved Domains (3) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:451 → 548
      BRF1; Brf1-like TBP-binding domain
      NF038052
      Location:499 → 627
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    2. XM_038674851.1 → XP_038530779.1  transcription factor IIIB 90 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    3. XM_038674852.1 → XP_038530780.1  transcription factor IIIB 90 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    4. XM_038674850.1 → XP_038530778.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (3) summary
      pfam07741
      Location:283 → 380
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:15 → 102
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:331 → 459
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      72556286..72608091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038484399.1 → XP_038340327.1  transcription factor IIIB 90 kDa subunit isoform X1

      Conserved Domains (3) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:451 → 548
      BRF1; Brf1-like TBP-binding domain
      NF038052
      Location:499 → 627
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    2. XM_038484401.1 → XP_038340329.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    3. XM_038484402.1 → XP_038340330.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    4. XM_038484400.1 → XP_038340328.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (3) summary
      pfam07741
      Location:283 → 380
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:15 → 102
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:331 → 459
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      72607209..72658851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038610004.1 → XP_038465932.1  transcription factor IIIB 90 kDa subunit isoform X1

      Conserved Domains (3) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:451 → 548
      BRF1; Brf1-like TBP-binding domain
      NF038052
      Location:499 → 627
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    2. XM_038610006.1 → XP_038465934.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    3. XM_038610007.1 → XP_038465935.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    4. XM_038610005.1 → XP_038465933.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (3) summary
      pfam07741
      Location:283 → 380
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:15 → 102
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:331 → 459
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      72997125..73048881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038545946.1 → XP_038401874.1  transcription factor IIIB 90 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A0A8C0K3Q3, A0A8C0MJG0, A0A8I3PEJ4
      Conserved Domains (3) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:451 → 548
      BRF1; Brf1-like TBP-binding domain
      NF038052
      Location:499 → 627
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    2. XM_038545947.1 → XP_038401875.1  transcription factor IIIB 90 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    3. XM_038545948.1 → XP_038401876.1  transcription factor IIIB 90 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    4. XM_038545949.1 → XP_038401877.1  transcription factor IIIB 90 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      72099839..72151572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038597168.1 → XP_038453096.1  transcription factor IIIB 90 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A0A8C0K3Q3, A0A8C0MJG0, A0A8I3PEJ4
      Conserved Domains (3) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:451 → 548
      BRF1; Brf1-like TBP-binding domain
      NF038052
      Location:499 → 627
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    2. XM_038597182.1 → XP_038453110.1  transcription factor IIIB 90 kDa subunit isoform X3

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    3. XM_005623891.4 → XP_005623948.1  transcription factor IIIB 90 kDa subunit isoform X3

      See identical proteins and their annotated locations for XP_005623948.1

      UniProtKB/TrEMBL
      A0A8C0PYS6
      Conserved Domains (3) summary
      pfam07741
      Location:247 → 344
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:1 → 66
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:295 → 423
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2

    4. XM_022422435.2 → XP_022278143.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (3) summary
      pfam07741
      Location:283 → 380
      BRF1; Brf1-like TBP-binding domain
      cd20554
      Location:15 → 102
      CYCLIN_TFIIIB90_rpt2; second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins
      NF038052
      Location:331 → 459
      histone_lik_HC2; histone H1-like DNA-binding protein Hc2
    Nucleotide Protein
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