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    METTL4 methyltransferase 4, N6-adenosine [ Canis lupus familiaris (dog) ]

    Gene ID: 490534, updated on 17-Aug-2024

    Summary

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    Official Symbol
    METTL4provided by VGNC
    Official Full Name
    methyltransferase 4, N6-adenosineprovided by VGNC
    Primary source
    VGNC:VGNC:43178
    See related
    Ensembl:ENSCAFG00845002376
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See METTL4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (69272450..69330069, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (68665874..68723331, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (69272402..69330056, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (68955089..69012718, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (68975650..69032839, complement)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096806 Neighboring gene casein kinase I-like Neighboring gene tubulin beta chain-like Neighboring gene uncharacterized LOC102152944 Neighboring gene NDC80 kinetochore complex component Neighboring gene actin, clone 302-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables site-specific DNA-methyltransferase (adenine-specific) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyltransferase-like protein 4; N(6)-adenine-specific methyltransferase METTL4
    Names
    methyltransferase like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      69272450..69330069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038672520.1 → XP_038528448.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L2A9, A0A8C0RKC8, A0A8C0RVN5, A0A8I3MPG5
      Related
      ENSCAFP00845003365.1, ENSCAFT00845004210.1
      Conserved Domains (1) summary
      cl01947
      Location:281 → 383
      MT-A70

    2. XM_038672516.1 → XP_038528444.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    3. XM_038672517.1 → XP_038528445.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Related
      ENSCAFP00845003355.1, ENSCAFT00845004196.1
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    4. XM_038672519.1 → XP_038528447.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    5. XM_038672518.1 → XP_038528446.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    RNA

    1. XR_005430315.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      68955089..69012718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038482276.1 → XP_038338204.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

      Conserved Domains (1) summary
      cl01947
      Location:281 → 383
      MT-A70

    2. XM_038482272.1 → XP_038338200.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    3. XM_038482273.1 → XP_038338201.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    4. XM_038482275.1 → XP_038338203.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    5. XM_038482274.1 → XP_038338202.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    RNA

    1. XR_005328748.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      68975650..69032839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038607837.1 → XP_038463765.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

      Conserved Domains (1) summary
      cl01947
      Location:281 → 383
      MT-A70

    2. XM_038607833.1 → XP_038463761.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    3. XM_038607834.1 → XP_038463762.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    4. XM_038607836.1 → XP_038463764.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    5. XM_038607835.1 → XP_038463763.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    RNA

    1. XR_005397110.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      69272402..69330056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038543711.1 → XP_038399639.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L2A9, A0A8C0RKC8, A0A8C0RVN5, A0A8I3MPG5
      Conserved Domains (1) summary
      cl01947
      Location:281 → 383
      MT-A70

    2. XM_038543707.1 → XP_038399635.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    3. XM_038543708.1 → XP_038399636.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    4. XM_038543710.1 → XP_038399638.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    5. XM_038543709.1 → XP_038399637.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8C0RVV3, A0A8I3RQN6
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70

    RNA

    1. XR_005362601.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      68665874..68723331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038576733.1 → XP_038432661.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RKC8, A0A8P0TGS0
      Conserved Domains (1) summary
      cl01947
      Location:281 → 383
      MT-A70

    2. XM_547656.7 → XP_547656.2  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      See identical proteins and their annotated locations for XP_547656.2

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8P0SML7
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70; MT-A70

    3. XM_005623026.4 → XP_005623083.1  N(6)-adenine-specific methyltransferase METTL4 isoform X1

      See identical proteins and their annotated locations for XP_005623083.1

      UniProtKB/TrEMBL
      A0A8C0NK03, A0A8P0SML7
      Conserved Domains (1) summary
      cl01947
      Location:281 → 454
      MT-A70; MT-A70

    RNA

    1. XR_005379819.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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