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    RASA4B RAS p21 protein activator 4B [ Canis lupus familiaris (dog) ]

    Gene ID: 489819, updated on 5-Mar-2024

    Summary

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    Gene symbol
    RASA4B
    Gene description
    RAS p21 protein activator 4B
    See related
    Ensembl:ENSCAFG00845004698
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    RASA4
    Orthologs
    human all
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    Genomic context

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    See RASA4B in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (7503229..7526168)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (9378179..9401012)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (7598480..7621454)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (7471860..7494678)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (7434857..7457744)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uroplakin 3B Neighboring gene uroplakin 3B like 2 Neighboring gene RNA polymerase II subunit J Neighboring gene leucine rich repeats and WD repeat domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating protein 4; ras GTPase-activating protein 4B
    Names
    RAS p21 protein activator 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      7503229..7526168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038667954.1 → XP_038523882.1  ras GTPase-activating protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0MJ45, A0A8C0R0E2, A0A8I3RS78
      Related
      ENSCAFP00845006640.1, ENSCAFT00845008432.1
      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    2. XM_038667953.1 → XP_038523881.1  ras GTPase-activating protein 4B isoform X1

      UniProtKB/TrEMBL
      A0A8C0KK49, A0A8C0MPZ6
      Related
      ENSCAFP00845006613.1, ENSCAFT00845008401.1
      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    3. XM_038667956.1 → XP_038523884.1  ras GTPase-activating protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0MJ45, A0A8C0MPH8, A0A8C0R0E2, A0A8I3MUR1, A0A8I3RS78
      Related
      ENSCAFP00845006668.1, ENSCAFT00845008463.1
      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    4. XM_038667955.1 → XP_038523883.1  ras GTPase-activating protein 4B isoform X3

      UniProtKB/TrEMBL
      A0A8C0QDT5
      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      7471860..7494678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038477921.1 → XP_038333849.1  ras GTPase-activating protein 4B isoform X2

      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    2. XM_038477920.1 → XP_038333848.1  ras GTPase-activating protein 4B isoform X1

      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    3. XM_038477923.1 → XP_038333851.1  ras GTPase-activating protein 4B isoform X4

      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    4. XM_038477922.1 → XP_038333850.1  ras GTPase-activating protein 4B isoform X3

      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      7434857..7457744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038603254.1 → XP_038459182.1  ras GTPase-activating protein 4B isoform X2

      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    2. XM_038603253.1 → XP_038459181.1  ras GTPase-activating protein 4B isoform X1

      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    3. XM_038603256.1 → XP_038459184.1  ras GTPase-activating protein 4B isoform X4

      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    4. XM_038603255.1 → XP_038459183.1  ras GTPase-activating protein 4B isoform X3

      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      7598480..7621454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038539169.1 → XP_038395097.1  ras GTPase-activating protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0MJ45, A0A8C0R0E2, A0A8I3RS78
      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    2. XM_038539168.1 → XP_038395096.1  ras GTPase-activating protein 4B isoform X5

      UniProtKB/TrEMBL
      A0A8P0TGI1

    3. XM_038539171.1 → XP_038395099.1  ras GTPase-activating protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0MJ45, A0A8C0MPH8, A0A8C0R0E2, A0A8I3MUR1, A0A8I3RS78
      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    4. XM_038539170.1 → XP_038395098.1  ras GTPase-activating protein 4B isoform X6

      UniProtKB/TrEMBL
      A0A8P0TGI1
      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9378179..9401012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005620995.4 → XP_005621052.1  ras GTPase-activating protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0MJ45, A0A8C0R0E2, A0A8I3RS78
      Conserved Domains (5) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    2. XM_014114180.3 → XP_013969655.1  ras GTPase-activating protein 4B isoform X7

      UniProtKB/TrEMBL
      A0A8P0TGI1
      Conserved Domains (7) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      smart00323
      Location:245 → 603
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13372
      Location:541 → 679
      PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
      pfam00169
      Location:566 → 668
      PH; PH domain
      pfam00779
      Location:679 → 707
      BTK; BTK motif

    3. XM_022419597.2 → XP_022275305.1  ras GTPase-activating protein 4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0MJ45, A0A8C0MPH8, A0A8C0R0E2, A0A8I3MUR1, A0A8I3RS78
      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain

    4. XM_038537603.1 → XP_038393531.1  ras GTPase-activating protein 4B isoform X8

      UniProtKB/TrEMBL
      A0A8P0TGI1
      Conserved Domains (4) summary
      cd04025
      Location:134 → 256
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:264 → 548
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      cl17171
      Location:541 → 633
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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