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    SHMT1 serine hydroxymethyltransferase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 489536, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SHMT1provided by VGNC
    Official Full Name
    serine hydroxymethyltransferase 1provided by VGNC
    Primary source
    VGNC:VGNC:46150
    See related
    Ensembl:ENSCAFG00845020125
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SHMT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (41329062..41356290)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (41361842..41388892)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (41435940..41463042)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (41296632..41323803)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (41244262..41272073)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83 member G Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene microRNA mir-8872 Neighboring gene DNA topoisomerase III alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, cytosolic
    XP_005620200.1
    XP_038331831.1
    XP_038331832.1
    XP_038393021.1
    XP_038393022.1
    XP_038457152.1
    XP_038457153.1
    XP_038521714.1
    XP_851819.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      41329062..41356290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038665786.1 → XP_038521714.1  serine hydroxymethyltransferase, cytosolic isoform X1

      UniProtKB/TrEMBL
      A0A8C0LY66, A0A8I3PGW1
      Related
      ENSCAFP00845027772.1, ENSCAFT00845035493.1
      Conserved Domains (1) summary
      PLN03226
      Location:25 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      41296632..41323803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038475903.1 → XP_038331831.1  serine hydroxymethyltransferase, cytosolic isoform X2

    2. XM_038475904.1 → XP_038331832.1  serine hydroxymethyltransferase, cytosolic isoform X2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      41244262..41272073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038601224.1 → XP_038457152.1  serine hydroxymethyltransferase, cytosolic isoform X3

    2. XM_038601225.1 → XP_038457153.1  serine hydroxymethyltransferase, cytosolic isoform X3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      41435940..41463042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038537093.1 → XP_038393021.1  serine hydroxymethyltransferase, cytosolic isoform X4

      UniProtKB/TrEMBL
      A0A8C0LY66, A0A8C0R542, A0A8C0RW38, A0A8I3PGW1, A0A8I3S1J1

    2. XM_038537094.1 → XP_038393022.1  serine hydroxymethyltransferase, cytosolic isoform X4

      UniProtKB/TrEMBL
      A0A8C0LY66, A0A8C0R542, A0A8C0RW38, A0A8I3PGW1, A0A8I3S1J1

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      41361842..41388892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_846726.6 → XP_851819.2  serine hydroxymethyltransferase, cytosolic isoform X5

      See identical proteins and their annotated locations for XP_851819.2

      UniProtKB/TrEMBL
      A0A8C0LY66, A0A8C0R542, A0A8C0RW38, A0A8I3PGW1, A0A8I3S1J1
      Conserved Domains (1) summary
      PLN03226
      Location:25 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    2. XM_005620143.4 → XP_005620200.1  serine hydroxymethyltransferase, cytosolic isoform X5

      See identical proteins and their annotated locations for XP_005620200.1

      UniProtKB/TrEMBL
      A0A8C0LY66, A0A8C0R542, A0A8C0RW38, A0A8I3PGW1, A0A8I3S1J1
      Conserved Domains (1) summary
      PLN03226
      Location:25 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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