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    ALKBH8 alkB homolog 8, tRNA methyltransferase [ Canis lupus familiaris (dog) ]

    Gene ID: 489424, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ALKBH8provided by VGNC
    Official Full Name
    alkB homolog 8, tRNA methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:37808
    See related
    Ensembl:ENSCAFG00845003777
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ALKBH8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (24846405..24927699)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (24735966..24816371)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (24849452..24928244)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (24898995..24979807)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (24787338..24866870)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene sarcolipin Neighboring gene ELMO domain containing 1 Neighboring gene rRNA N6-adenosine-methyltransferase METTL5-like Neighboring gene uncharacterized LOC119871823 Neighboring gene small nucleolar RNA SNORA61 Neighboring gene CWF19 like cell cycle control factor 2 Neighboring gene uncharacterized LOC111096102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alkylated DNA repair protein alkB homolog 8
    Names
    alkB, alkylation repair homolog 8
    XP_005619894.1
    XP_038331090.1
    XP_038331091.1
    XP_038331092.1
    XP_038331093.1
    XP_038331094.1
    XP_038367706.1
    XP_038367717.1
    XP_038367726.1
    XP_038392221.1
    XP_038392222.1
    XP_038392223.1
    XP_038392224.1
    XP_038392225.1
    XP_038456420.1
    XP_038456421.1
    XP_038456422.1
    XP_038456423.1
    XP_038456424.1
    XP_038520948.1
    XP_038520949.1
    XP_038520950.1
    XP_038520951.1
    XP_038520952.1
    XP_546542.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      24846405..24927699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038665022.1 → XP_038520950.1  alkylated DNA repair protein alkB homolog 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I3MSF4
      Conserved Domains (4) summary
      pfam09004
      Location:15 → 51
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:424 → 511
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:56 → 136
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:147 → 317
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_038665023.1 → XP_038520951.1  alkylated DNA repair protein alkB homolog 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I3MSF4, A0A8I3RT37
      Related
      ENSCAFP00845005358.1, ENSCAFT00845006739.1
      Conserved Domains (4) summary
      pfam09004
      Location:14 → 50
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:423 → 510
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:55 → 135
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:146 → 316
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    3. XM_038665021.1 → XP_038520949.1  alkylated DNA repair protein alkB homolog 8 isoform X2

      Conserved Domains (4) summary
      pfam09004
      Location:127 → 163
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:536 → 623
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:168 → 248
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:259 → 429
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. XM_038665020.1 → XP_038520948.1  alkylated DNA repair protein alkB homolog 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3MSF4
      Conserved Domains (4) summary
      pfam09004
      Location:127 → 163
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:536 → 623
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:168 → 248
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:259 → 429
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    5. XM_038665024.1 → XP_038520952.1  alkylated DNA repair protein alkB homolog 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I3MSF4
      Related
      ENSCAFP00845005365.1, ENSCAFT00845006749.1
      Conserved Domains (4) summary
      pfam09004
      Location:1 → 37
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:410 → 497
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:42 → 122
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:133 → 303
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      24898995..24979807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038475164.1 → XP_038331092.1  alkylated DNA repair protein alkB homolog 8 isoform X3

      Conserved Domains (4) summary
      pfam09004
      Location:15 → 51
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:424 → 511
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:56 → 136
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:147 → 317
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_038475165.1 → XP_038331093.1  alkylated DNA repair protein alkB homolog 8 isoform X4

    3. XM_038475163.1 → XP_038331091.1  alkylated DNA repair protein alkB homolog 8 isoform X2

    4. XM_038475162.1 → XP_038331090.1  alkylated DNA repair protein alkB homolog 8 isoform X1

    5. XM_038475166.1 → XP_038331094.1  alkylated DNA repair protein alkB homolog 8 isoform X5

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      24787338..24866870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038600494.1 → XP_038456422.1  alkylated DNA repair protein alkB homolog 8 isoform X3

      Conserved Domains (4) summary
      pfam09004
      Location:15 → 51
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:424 → 511
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:56 → 136
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:147 → 317
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_038600495.1 → XP_038456423.1  alkylated DNA repair protein alkB homolog 8 isoform X4

    3. XM_038600493.1 → XP_038456421.1  alkylated DNA repair protein alkB homolog 8 isoform X2

      Conserved Domains (4) summary
      pfam09004
      Location:127 → 163
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:536 → 623
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:168 → 248
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:259 → 429
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. XM_038600492.1 → XP_038456420.1  alkylated DNA repair protein alkB homolog 8 isoform X1

      Conserved Domains (4) summary
      pfam09004
      Location:127 → 163
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:536 → 623
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:168 → 248
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:259 → 429
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    5. XM_038600496.1 → XP_038456424.1  alkylated DNA repair protein alkB homolog 8 isoform X5

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      24849452..24928244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038536295.1 → XP_038392223.1  alkylated DNA repair protein alkB homolog 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I3MSF4

    2. XM_038536296.1 → XP_038392224.1  alkylated DNA repair protein alkB homolog 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0K4Q8, A0A8I3MSF4

    3. XM_038536294.1 → XP_038392222.1  alkylated DNA repair protein alkB homolog 8 isoform X2

    4. XM_038536293.1 → XP_038392221.1  alkylated DNA repair protein alkB homolog 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3MSF4

    5. XM_038536297.1 → XP_038392225.1  alkylated DNA repair protein alkB homolog 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I3MSF4

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      24735966..24816371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038511798.1 → XP_038367726.1  alkylated DNA repair protein alkB homolog 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0MN23, A0A8I3MSF4
      Conserved Domains (4) summary
      pfam09004
      Location:15 → 51
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:424 → 511
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:56 → 136
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:147 → 317
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_546542.7 → XP_546542.3  alkylated DNA repair protein alkB homolog 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0SHI8, A0A8I3MSF4, A0A8P0NGG0
      Conserved Domains (4) summary
      pfam09004
      Location:14 → 50
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:55 → 135
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam08241
      Location:425 → 514
      Methyltransf_11; Methyltransferase domain
      cl21496
      Location:146 → 316
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    3. XM_038511789.1 → XP_038367717.1  alkylated DNA repair protein alkB homolog 8 isoform X2

      Conserved Domains (4) summary
      pfam09004
      Location:127 → 163
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:536 → 623
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:168 → 248
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:259 → 429
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. XM_038511778.1 → XP_038367706.1  alkylated DNA repair protein alkB homolog 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3MSF4
      Conserved Domains (4) summary
      pfam09004
      Location:127 → 163
      DUF1891; Domain of unknown function (DUF1891)
      pfam13649
      Location:536 → 623
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:168 → 248
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:259 → 429
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    5. XM_005619837.4 → XP_005619894.1  alkylated DNA repair protein alkB homolog 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I3MSF4
      Conserved Domains (4) summary
      pfam09004
      Location:1 → 37
      DUF1891; Domain of unknown function (DUF1891)
      cd12431
      Location:42 → 122
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam08241
      Location:412 → 501
      Methyltransf_11; Methyltransferase domain
      cl21496
      Location:133 → 303
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    Nucleotide Protein
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