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    PCSK6 proprotein convertase subtilisin/kexin type 6 [ Canis lupus familiaris (dog) ]

    Gene ID: 488703, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PCSK6provided by VGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 6provided by VGNC
    Primary source
    VGNC:VGNC:53196
    See related
    Ensembl:ENSCAFG00845000759
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (39974680..40160403)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (42273277..42458425)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (39946780..40132048)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (39508310..39693874)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (39735714..39930680)

    Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene DCN1-like protein 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ribosomal protein L31 pseudogene Neighboring gene uncharacterized LOC119871193 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene uncharacterized LOC106558604 Neighboring gene selenoprotein S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 6
    XP_038327638.1
    XP_038327639.1
    XP_038327640.1
    XP_038329066.1
    XP_038329074.1
    XP_038329082.1
    XP_038388561.1
    XP_038388562.1
    XP_038388563.1
    XP_038453905.1
    XP_038517075.1
    XP_038517076.1
    XP_038517077.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051807.1 Reference ROS_Cfam_1.0

      Range
      39974680..40160403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038661147.1 → XP_038517075.1  proprotein convertase subtilisin/kexin type 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0L7X2, A0A8I3MGG5
      Related
      ENSCAFP00845000988.1, ENSCAFT00845001285.1
      Conserved Domains (7) summary
      cd04059
      Location:166 → 460
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:850 → 892
      FU; Furin-like repeats
      cd00064
      Location:805 → 851
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:545 → 635
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:948 → 971
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:701 → 810
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:79 → 155
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038661148.1 → XP_038517076.1  proprotein convertase subtilisin/kexin type 6 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L7X2, A0A8I3MIN7
      Related
      ENSCAFP00845001015.1, ENSCAFT00845001316.1
      Conserved Domains (7) summary
      cd04059
      Location:166 → 460
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:837 → 879
      FU; Furin-like repeats
      cd00064
      Location:792 → 838
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:545 → 635
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:935 → 958
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:688 → 797
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:79 → 155
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038661149.1 → XP_038517077.1  proprotein convertase subtilisin/kexin type 6 isoform X3

      UniProtKB/TrEMBL
      A0A8C0TMI5
      Conserved Domains (2) summary
      cd04059
      Location:166 → 460
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:79 → 155
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049263.1 Alternate UMICH_Zoey_3.1

      Range
      39508310..39693874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038471710.1 → XP_038327638.1  proprotein convertase subtilisin/kexin type 6 isoform X1

      Conserved Domains (7) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:849 → 891
      FU; Furin-like repeats
      cd00064
      Location:804 → 850
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:544 → 634
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:947 → 970
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:700 → 809
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038471711.1 → XP_038327639.1  proprotein convertase subtilisin/kexin type 6 isoform X2

      Conserved Domains (7) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:836 → 878
      FU; Furin-like repeats
      cd00064
      Location:791 → 837
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:544 → 634
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:934 → 957
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:687 → 796
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038471712.1 → XP_038327640.1  proprotein convertase subtilisin/kexin type 6 isoform X3

      Conserved Domains (2) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

      Range
      39735714..39930680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038597977.1 → XP_038453905.1  proprotein convertase subtilisin/kexin type 6 isoform X4

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

      Range
      39946780..40132048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038532633.1 → XP_038388561.1  proprotein convertase subtilisin/kexin type 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0L7X2, A0A8C0LY41, A0A8P0NCJ8
      Conserved Domains (7) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:849 → 891
      FU; Furin-like repeats
      cd00064
      Location:804 → 850
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:544 → 634
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:947 → 970
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:700 → 809
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038532634.1 → XP_038388562.1  proprotein convertase subtilisin/kexin type 6 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L7X2, A0A8C0M1Y3, A0A8P0THU4
      Conserved Domains (7) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:836 → 878
      FU; Furin-like repeats
      cd00064
      Location:791 → 837
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:544 → 634
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:934 → 957
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:687 → 796
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038532635.1 → XP_038388563.1  proprotein convertase subtilisin/kexin type 6 isoform X3

      UniProtKB/TrEMBL
      A0A8C0TMI5

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      42273277..42458425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473138.1 → XP_038329066.1  proprotein convertase subtilisin/kexin type 6 isoform X1

      UniProtKB/TrEMBL
      A0A8C0L7X2, A0A8C0LY41, A0A8P0NCJ8
      Conserved Domains (7) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:849 → 891
      FU; Furin-like repeats
      cd00064
      Location:804 → 850
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:544 → 634
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:947 → 970
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:700 → 809
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_038473146.1 → XP_038329074.1  proprotein convertase subtilisin/kexin type 6 isoform X2

      UniProtKB/TrEMBL
      A0A8C0L7X2, A0A8C0M1Y3, A0A8P0THU4
      Conserved Domains (7) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:836 → 878
      FU; Furin-like repeats
      cd00064
      Location:791 → 837
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:544 → 634
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:934 → 957
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:687 → 796
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_038473154.1 → XP_038329082.1  proprotein convertase subtilisin/kexin type 6 isoform X3

      UniProtKB/TrEMBL
      A0A8C0TMI5
      Conserved Domains (2) summary
      cd04059
      Location:165 → 459
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:78 → 154
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
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