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    UBR1 ubiquitin protein ligase E3 component n-recognin 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 487521, updated on 17-Aug-2024

    Summary

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    Official Symbol
    UBR1provided by VGNC
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 1provided by VGNC
    Primary source
    VGNC:VGNC:48089
    See related
    Ensembl:ENSCAFG00845021765
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See UBR1 in Genome Data Viewer
    Location:
    chromosome: 30
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (10005751..10143458, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (9926950..10066799, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (10161091..10301368, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (9920878..10060694, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (10043912..10181675, complement)

    Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene heat shock protein HSP 90-alpha-like Neighboring gene uncharacterized LOC111093378 Neighboring gene transmembrane protein 62 Neighboring gene cyclin D1 binding protein 1 Neighboring gene uncharacterized LOC111093331 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene transglutaminase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR1
    XP_005638377.1
    XP_022268616.1
    XP_038298031.1
    XP_038298032.1
    XP_038298033.1
    XP_038372505.1
    XP_038372506.1
    XP_038372507.1
    XP_038436118.1
    XP_038436119.1
    XP_038436120.1
    XP_038500403.1
    XP_038500404.1
    XP_038500405.1
    XP_544645.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051834.1 Reference ROS_Cfam_1.0

      Range
      10005751..10143458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038442103.1 → XP_038298031.1  E3 ubiquitin-protein ligase UBR1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SWA7
      Conserved Domains (4) summary
      cd16685
      Location:1141 → 1259
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:143 → 210
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:265 → 345
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1345 → 1772
      PRT6_C; Proteolysis_6 C-terminal

    2. XM_038442105.1 → XP_038298033.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0SWA7
      Conserved Domains (4) summary
      cd16685
      Location:1043 → 1161
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:45 → 112
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:167 → 247
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1247 → 1674
      PRT6_C; Proteolysis_6 C-terminal

    3. XM_038442104.1 → XP_038298032.1  E3 ubiquitin-protein ligase UBR1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RPV6, A0A8C0RPY2, A0A8I3P974
      Related
      ENSCAFP00845030089.1, ENSCAFT00845038432.1
      Conserved Domains (4) summary
      cd16685
      Location:1097 → 1215
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:221 → 301
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1301 → 1728
      PRT6_C; Proteolysis_6 C-terminal

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049290.1 Alternate UMICH_Zoey_3.1

      Range
      9920878..10060694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038516577.1 → XP_038372505.1  E3 ubiquitin-protein ligase UBR1 isoform X1

      Conserved Domains (4) summary
      cd16685
      Location:1141 → 1259
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:143 → 210
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:265 → 345
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1345 → 1772
      PRT6_C; Proteolysis_6 C-terminal

    2. XM_038516579.1 → XP_038372507.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      Conserved Domains (4) summary
      cd16685
      Location:1043 → 1161
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:45 → 112
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:167 → 247
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1247 → 1674
      PRT6_C; Proteolysis_6 C-terminal

    3. XM_038516578.1 → XP_038372506.1  E3 ubiquitin-protein ligase UBR1 isoform X2

      Conserved Domains (4) summary
      cd16685
      Location:1097 → 1215
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:221 → 301
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1301 → 1728
      PRT6_C; Proteolysis_6 C-terminal

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

      Range
      10043912..10181675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038644475.1 → XP_038500403.1  E3 ubiquitin-protein ligase UBR1 isoform X2

      Conserved Domains (4) summary
      cd16685
      Location:1097 → 1215
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:221 → 301
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1301 → 1728
      PRT6_C; Proteolysis_6 C-terminal

    2. XM_038644477.1 → XP_038500405.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      Conserved Domains (4) summary
      cd16685
      Location:1043 → 1161
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:45 → 112
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:167 → 247
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1247 → 1674
      PRT6_C; Proteolysis_6 C-terminal

    3. XM_038644476.1 → XP_038500404.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      Conserved Domains (4) summary
      cd16685
      Location:1043 → 1161
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:45 → 112
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:167 → 247
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1247 → 1674
      PRT6_C; Proteolysis_6 C-terminal

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

      Range
      10161091..10301368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038580190.1 → XP_038436118.1  E3 ubiquitin-protein ligase UBR1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RPY2

    2. XM_038580192.1 → XP_038436120.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0SWA7

    3. XM_038580191.1 → XP_038436119.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0SWA7

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9926950..10066799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005638320.4 → XP_005638377.1  E3 ubiquitin-protein ligase UBR1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SWA7
      Conserved Domains (4) summary
      cd16685
      Location:1141 → 1259
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:143 → 210
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:265 → 345
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1345 → 1772
      PRT6_C; Proteolysis_6 C-terminal

    2. XM_022412908.2 → XP_022268616.1  E3 ubiquitin-protein ligase UBR1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0SWA7
      Conserved Domains (4) summary
      cd16685
      Location:1043 → 1161
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:45 → 112
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:167 → 247
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1247 → 1674
      PRT6_C; Proteolysis_6 C-terminal

    3. XM_544645.7 → XP_544645.2  E3 ubiquitin-protein ligase UBR1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RPV6, A0A8C0RPY2, A0A8I3P974
      Conserved Domains (4) summary
      cd16685
      Location:1097 → 1215
      RING-H2_UBR1; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1) and similar proteins
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:221 → 301
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
      pfam18995
      Location:1301 → 1728
      PRT6_C; Proteolysis_6 C-terminal
    Nucleotide Protein
    Heading Accession and Version

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