U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 486984, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PREX2provided by VGNC
    Official Full Name
    phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2provided by VGNC
    Primary source
    VGNC:VGNC:44963
    See related
    Ensembl:ENSCAFG00845022878
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    DEPDC2
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PREX2 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 29 NC_051833.1 (17543026..17827957)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 29 NC_006611.4 (17773929..18057994)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 29 NC_049250.1 (17936353..18212814)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 29 NC_049289.1 (17589003..17873821)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 29 NC_049770.1 (17666595..17943382)

    Chromosome 29 - NC_051833.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093201 Neighboring gene RNA-binding motif protein, X chromosome Neighboring gene uncharacterized LOC119866712 Neighboring gene THUMP domain-containing protein 3-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
    Names
    DEP domain containing 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051833.1 Reference ROS_Cfam_1.0

      Range
      17543026..17827957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038441338.1 → XP_038297266.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

      UniProtKB/TrEMBL
      A0A8C0MV42, A0A8C0TJF4, A0A8I3PDR7
      Related
      ENSCAFP00845031893.1, ENSCAFT00845040740.1
      Conserved Domains (6) summary
      smart00228
      Location:675 → 743
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd04439
      Location:382 → 462
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:474 → 566
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:218 → 364
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:27 → 212
      RhoGEF; RhoGEF domain
      pfam17820
      Location:615 → 668
      PDZ_6; PDZ domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049289.1 Alternate UMICH_Zoey_3.1

      Range
      17589003..17873821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038515913.1 → XP_038371841.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049770.1 Alternate UNSW_CanFamBas_1.0

      Range
      17666595..17943382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038643726.1 → XP_038499654.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

      Conserved Domains (6) summary
      smart00228
      Location:675 → 743
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd04439
      Location:382 → 462
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:474 → 566
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:218 → 364
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:27 → 212
      RhoGEF; RhoGEF domain
      pfam17820
      Location:615 → 668
      PDZ_6; PDZ domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049250.1 Alternate UU_Cfam_GSD_1.0

      Range
      17936353..18212814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038579474.1 → XP_038435402.1  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

      UniProtKB/TrEMBL
      A0A8C0TJF4

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006611.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      17773929..18057994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_544113.7 → XP_544113.4  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

      UniProtKB/TrEMBL
      A0A8C0MV42, A0A8C0TJF4, A0A8I3PDR7
      Conserved Domains (6) summary
      smart00228
      Location:675 → 743
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd04439
      Location:382 → 462
      DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd04440
      Location:474 → 566
      DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
      cd01224
      Location:218 → 364
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00621
      Location:27 → 212
      RhoGEF; RhoGEF domain
      pfam17820
      Location:615 → 668
      PDZ_6; PDZ domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials