USP18 ubiquitin specific peptidase 18 [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: USP18
Gene description: ubiquitin specific peptidase 18
See related: Ensembl:ENSCAFG00845030962
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (46107395..46183398)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (868159..943927, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (223830..299560, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (46041070..46116807)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (46008145..46083815)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ubl carboxyl-terminal hydrolase 18

XP_005637457.1

EC 3.1.2.-

EC 3.4.19.12

XP_005637458.1

EC 3.1.2.-

EC 3.4.19.12

XP_005637459.1

EC 3.1.2.-

EC 3.4.19.12

XP_005637461.1

EC 3.1.2.-

EC 3.4.19.12

XP_013964200.1

EC 3.1.2.-

EC 3.4.19.12

XP_013964201.1

EC 3.1.2.-

EC 3.4.19.12

XP_013964202.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295498.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295499.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295500.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295501.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295502.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295503.1

EC 3.1.2.-

EC 3.4.19.12

XP_038295504.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370150.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370151.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370152.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370153.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370155.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370156.1

EC 3.1.2.-

EC 3.4.19.12

XP_038370157.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432123.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432124.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432125.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432126.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432127.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432128.1

EC 3.1.2.-

EC 3.4.19.12

XP_038432129.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498006.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498007.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498008.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498009.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498010.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498011.1

EC 3.1.2.-

EC 3.4.19.12

XP_038498013.1

EC 3.1.2.-

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051831.1 Reference ROS_Cfam_1.0

Range

46107395..46183398

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038439570.1 → XP_038295498.1 ubl carboxyl-terminal hydrolase 18 isoform X1

UniProtKB/TrEMBL

A0A8C0RUC2, A0A8C0TA33, A0A8P0TNI1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038439575.1 → XP_038295503.1 ubl carboxyl-terminal hydrolase 18 isoform X4

UniProtKB/TrEMBL

A0A8C0K096

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038439576.1 → XP_038295504.1 ubl carboxyl-terminal hydrolase 18 isoform X5

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038439571.1 → XP_038295499.1 ubl carboxyl-terminal hydrolase 18 isoform X1

UniProtKB/TrEMBL

A0A8C0RUC2, A0A8C0TA33, A0A8P0TNI1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038439573.1 → XP_038295501.1 ubl carboxyl-terminal hydrolase 18 isoform X3

UniProtKB/TrEMBL

A0A8C0K096, A0A8P0SKT1

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_038439572.1 → XP_038295500.1 ubl carboxyl-terminal hydrolase 18 isoform X2

UniProtKB/TrEMBL

A0A8C0RUC2

Related

ENSCAFP00845043286.1, ENSCAFT00845055052.1

Conserved Domains (1) summary

pfam00443
Location:22 → 315

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038439574.1 → XP_038295502.1 ubl carboxyl-terminal hydrolase 18 isoform X3

UniProtKB/TrEMBL

A0A8C0K096, A0A8P0SKT1

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049287.1 Alternate UMICH_Zoey_3.1

Range

46041070..46116807

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038514222.1 → XP_038370150.1 ubl carboxyl-terminal hydrolase 18 isoform X1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038514228.1 → XP_038370156.1 ubl carboxyl-terminal hydrolase 18 isoform X4

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038514229.1 → XP_038370157.1 ubl carboxyl-terminal hydrolase 18 isoform X5

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038514223.1 → XP_038370151.1 ubl carboxyl-terminal hydrolase 18 isoform X1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038514225.1 → XP_038370153.1 ubl carboxyl-terminal hydrolase 18 isoform X3

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_038514224.1 → XP_038370152.1 ubl carboxyl-terminal hydrolase 18 isoform X2

Conserved Domains (1) summary

pfam00443
Location:22 → 315

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038514227.1 → XP_038370155.1 ubl carboxyl-terminal hydrolase 18 isoform X3

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049768.1 Alternate UNSW_CanFamBas_1.0

Range

46008145..46083815

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038642078.1 → XP_038498006.1 ubl carboxyl-terminal hydrolase 18 isoform X1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038642083.1 → XP_038498011.1 ubl carboxyl-terminal hydrolase 18 isoform X4

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038642085.1 → XP_038498013.1 ubl carboxyl-terminal hydrolase 18 isoform X5

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038642079.1 → XP_038498007.1 ubl carboxyl-terminal hydrolase 18 isoform X1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038642081.1 → XP_038498009.1 ubl carboxyl-terminal hydrolase 18 isoform X3

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_038642080.1 → XP_038498008.1 ubl carboxyl-terminal hydrolase 18 isoform X2

Conserved Domains (1) summary

pfam00443
Location:22 → 315

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038642082.1 → XP_038498010.1 ubl carboxyl-terminal hydrolase 18 isoform X3

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049248.1 Alternate UU_Cfam_GSD_1.0

Range

223830..299560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038576198.1 → XP_038432126.1 ubl carboxyl-terminal hydrolase 18 isoform X3

UniProtKB/TrEMBL

A0A8C0K096, A0A8P0SKT1

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_038576196.1 → XP_038432124.1 ubl carboxyl-terminal hydrolase 18 isoform X1

UniProtKB/TrEMBL

A0A8C0RUC2, A0A8C0TA33, A0A8P0TNI1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038576201.1 → XP_038432129.1 ubl carboxyl-terminal hydrolase 18 isoform X5

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038576200.1 → XP_038432128.1 ubl carboxyl-terminal hydrolase 18 isoform X4

UniProtKB/TrEMBL

A0A8C0K096

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038576195.1 → XP_038432123.1 ubl carboxyl-terminal hydrolase 18 isoform X1

UniProtKB/TrEMBL

A0A8C0RUC2, A0A8C0TA33, A0A8P0TNI1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_038576199.1 → XP_038432127.1 ubl carboxyl-terminal hydrolase 18 isoform X3

UniProtKB/TrEMBL

A0A8C0K096, A0A8P0SKT1

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_038576197.1 → XP_038432125.1 ubl carboxyl-terminal hydrolase 18 isoform X2

UniProtKB/TrEMBL

A0A8C0RUC2

Conserved Domains (1) summary

pfam00443
Location:22 → 315

UCH; Ubiquitin carboxyl-terminal hydrolase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

868159..943927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_014108725.3 → XP_013964200.1 ubl carboxyl-terminal hydrolase 18 isoform X3

UniProtKB/TrEMBL

A0A8C0K096, A0A8P0SKT1

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_005637401.3 → XP_005637458.1 ubl carboxyl-terminal hydrolase 18 isoform X1

See identical proteins and their annotated locations for XP_005637458.1

UniProtKB/TrEMBL

A0A8C0RUC2, A0A8C0TA33, A0A8P0TNI1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_005637404.3 → XP_005637461.1 ubl carboxyl-terminal hydrolase 18 isoform X5

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_014108727.3 → XP_013964202.1 ubl carboxyl-terminal hydrolase 18 isoform X4

UniProtKB/TrEMBL

A0A8C0K096

Conserved Domains (1) summary

pfam00443
Location:22 → 249

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_005637400.3 → XP_005637457.1 ubl carboxyl-terminal hydrolase 18 isoform X1

See identical proteins and their annotated locations for XP_005637457.1

UniProtKB/TrEMBL

A0A8C0RUC2, A0A8C0TA33, A0A8P0TNI1

Conserved Domains (1) summary

pfam00443
Location:22 → 334

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_014108726.3 → XP_013964201.1 ubl carboxyl-terminal hydrolase 18 isoform X3

UniProtKB/TrEMBL

A0A8C0K096, A0A8P0SKT1

Conserved Domains (1) summary

cd02257
Location:63 → 294

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_005637402.3 → XP_005637459.1 ubl carboxyl-terminal hydrolase 18 isoform X2

UniProtKB/TrEMBL

A0A8C0RUC2

Conserved Domains (1) summary

pfam00443
Location:22 → 315

UCH; Ubiquitin carboxyl-terminal hydrolase