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    SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 485862, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SAMHD1provided by VGNC
    Official Full Name
    SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1provided by VGNC
    Primary source
    VGNC:VGNC:45856
    See related
    Ensembl:ENSCAFG00845026832
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SAMHD1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (26321372..26377665, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (25269008..25324975, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (26189021..26245159, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (25599032..25655273, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (25699545..25755789, complement)

    Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene DSN1 component of MIS12 kinetochore complex Neighboring gene microtubule crosslinking factor 2 Neighboring gene TBC/LysM-associated domain containing 2 Neighboring gene RB transcriptional corepressor like 1 Neighboring gene uncharacterized LOC111092069 Neighboring gene maestro heat like repeat family member 8 Neighboring gene uncharacterized LOC111092070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dGTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dGTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deoxynucleoside triphosphate triphosphohydrolase SAMHD1
    XP_038289687.1
    XP_038289688.1
    XP_038313416.1
    XP_038364835.1
    XP_038364836.1
    XP_038428168.1
    XP_038428169.1
    XP_038492425.1
    XP_038492426.1
    XP_542986.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051828.1 Reference ROS_Cfam_1.0

      Range
      26321372..26377665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038433760.1 → XP_038289688.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KDS7
      Conserved Domains (2) summary
      COG1078
      Location:71 → 485
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
      cl15755
      Location:8 → 66
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_038433759.1 → XP_038289687.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KFU8, A0A8C0SIE9, A0A8I3PZF8
      Related
      ENSCAFP00845037141.1, ENSCAFT00845047328.1
      Conserved Domains (2) summary
      cd09508
      Location:41 → 110
      SAM_HD; SAM domain of HD-phosphohydrolase
      COG1078
      Location:115 → 529
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049284.1 Alternate UMICH_Zoey_3.1

      Range
      25599032..25655273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038508908.1 → XP_038364836.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2

      Conserved Domains (2) summary
      COG1078
      Location:71 → 485
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
      cl15755
      Location:8 → 66
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_038508907.1 → XP_038364835.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

      Conserved Domains (2) summary
      cd09508
      Location:41 → 110
      SAM_HD; SAM domain of HD-phosphohydrolase
      COG1078
      Location:115 → 529
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

      Range
      25699545..25755789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038636498.1 → XP_038492426.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2

      Conserved Domains (2) summary
      COG1078
      Location:71 → 485
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
      cl15755
      Location:8 → 66
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_038636497.1 → XP_038492425.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

      Conserved Domains (2) summary
      cd09508
      Location:41 → 110
      SAM_HD; SAM domain of HD-phosphohydrolase
      COG1078
      Location:115 → 529
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

      Range
      26189021..26245159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038572241.1 → XP_038428169.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KDS7
      Conserved Domains (2) summary
      COG1078
      Location:71 → 485
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
      cl15755
      Location:8 → 66
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_038572240.1 → XP_038428168.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KFU8, A0A8C0SIE9, A0A8I3PZF8
      Conserved Domains (2) summary
      cd09508
      Location:41 → 110
      SAM_HD; SAM domain of HD-phosphohydrolase
      COG1078
      Location:115 → 529
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      25269008..25324975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038457488.1 → XP_038313416.1  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KDS7
      Conserved Domains (2) summary
      COG1078
      Location:71 → 485
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
      cl15755
      Location:8 → 66
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_542986.7 → XP_542986.3  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KFU8, A0A8C0SIE9, A0A8I3PZF8
      Conserved Domains (2) summary
      cd09508
      Location:41 → 110
      SAM_HD; SAM domain of HD-phosphohydrolase
      COG1078
      Location:115 → 529
      YdhJ; HD superfamily phosphohydrolase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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