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    SLCO2B1 solute carrier organic anion transporter family member 2B1 [ Canis lupus familiaris (dog) ]

    Gene ID: 485192, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SLCO2B1provided by VGNC
    Official Full Name
    solute carrier organic anion transporter family member 2B1provided by VGNC
    Primary source
    VGNC:VGNC:46496
    See related
    Ensembl:ENSCAFG00845012322
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SLCO2B1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (23549950..23595798, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (23112620..23158473, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (23462533..23508286, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (23348431..23394289, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (23544699..23590501, complement)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene nucleoside diphosphate kinase, mitochondrial-like Neighboring gene trophoblast glycoprotein like Neighboring gene olfactory receptor family 2 subfamily AT member 5, pseudogene Neighboring gene olfactory receptor family 2 subfamily AT member 8, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. Köck K, et al. J Biol Chem, 2010 Apr 9. PMID 20159975, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OATP2B1/SLCO2B1 function is modulated by protein kinase C-mediated internalization
      Title: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 2B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      23549950..23595798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038430081.1 → XP_038286009.1  solute carrier organic anion transporter family member 2B1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JML1, A0A8C0NP60, A0A8C0NPL4
      Related
      ENSCAFP00845017289.1, ENSCAFT00845021991.1
      Conserved Domains (1) summary
      cl28910
      Location:48 → 590
      MFS; Major Facilitator Superfamily

    2. XM_038430080.1 → XP_038286008.1  solute carrier organic anion transporter family member 2B1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NP60
      Conserved Domains (1) summary
      cl28910
      Location:58 → 599
      MFS; Major Facilitator Superfamily

    3. XM_038430079.1 → XP_038286007.1  solute carrier organic anion transporter family member 2B1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NP60, A0A8I3NMC0, A0A8P0NU97
      Related
      ENSCAFP00845017315.1, ENSCAFT00845022027.1
      Conserved Domains (1) summary
      cl28910
      Location:58 → 600
      MFS; Major Facilitator Superfamily

    4. XM_038430082.1 → XP_038286010.1  solute carrier organic anion transporter family member 2B1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NP60, A0A8C0SY52
      Conserved Domains (1) summary
      cl28910
      Location:35 → 577
      MFS; Major Facilitator Superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      23348431..23394289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038505460.1 → XP_038361388.1  solute carrier organic anion transporter family member 2B1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:48 → 590
      MFS; Major Facilitator Superfamily

    2. XM_038505459.1 → XP_038361387.1  solute carrier organic anion transporter family member 2B1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:58 → 599
      MFS; Major Facilitator Superfamily

    3. XM_038505458.1 → XP_038361386.1  solute carrier organic anion transporter family member 2B1 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:58 → 600
      MFS; Major Facilitator Superfamily

    4. XM_038505461.1 → XP_038361389.1  solute carrier organic anion transporter family member 2B1 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:35 → 577
      MFS; Major Facilitator Superfamily

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      23544699..23590501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038632788.1 → XP_038488716.1  solute carrier organic anion transporter family member 2B1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:48 → 590
      MFS; Major Facilitator Superfamily

    2. XM_038632787.1 → XP_038488715.1  solute carrier organic anion transporter family member 2B1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:58 → 599
      MFS; Major Facilitator Superfamily

    3. XM_038632786.1 → XP_038488714.1  solute carrier organic anion transporter family member 2B1 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:58 → 600
      MFS; Major Facilitator Superfamily

    4. XM_038632789.1 → XP_038488717.1  solute carrier organic anion transporter family member 2B1 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:35 → 577
      MFS; Major Facilitator Superfamily

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      23462533..23508286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038568619.1 → XP_038424547.1  solute carrier organic anion transporter family member 2B1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JML1, A0A8C0NP60, A0A8C0NPL4
      Conserved Domains (1) summary
      cl28910
      Location:48 → 590
      MFS; Major Facilitator Superfamily

    2. XM_038568617.1 → XP_038424545.1  solute carrier organic anion transporter family member 2B1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NP60
      Conserved Domains (1) summary
      cl28910
      Location:58 → 599
      MFS; Major Facilitator Superfamily

    3. XM_038568616.1 → XP_038424544.1  solute carrier organic anion transporter family member 2B1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NP60, A0A8I3NMC0, A0A8P0NU97
      Conserved Domains (1) summary
      cl28910
      Location:58 → 600
      MFS; Major Facilitator Superfamily

    4. XM_038568620.1 → XP_038424548.1  solute carrier organic anion transporter family member 2B1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NP60, A0A8C0SY52
      Conserved Domains (1) summary
      cl28910
      Location:35 → 577
      MFS; Major Facilitator Superfamily

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23112620..23158473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005633497.4 → XP_005633554.1  solute carrier organic anion transporter family member 2B1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JML1, A0A8C0NP60, A0A8C0NPL4
      Conserved Domains (1) summary
      cl28910
      Location:48 → 590
      MFS; Major Facilitator Superfamily

    2. XM_005633496.4 → XP_005633553.1  solute carrier organic anion transporter family member 2B1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NP60
      Conserved Domains (1) summary
      cl28910
      Location:58 → 599
      MFS; Major Facilitator Superfamily

    3. XM_005633495.4 → XP_005633552.1  solute carrier organic anion transporter family member 2B1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NP60, A0A8I3NMC0, A0A8P0NU97
      Conserved Domains (1) summary
      cl28910
      Location:58 → 600
      MFS; Major Facilitator Superfamily

    4. XM_005633498.4 → XP_005633555.1  solute carrier organic anion transporter family member 2B1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NP60, A0A8C0SY52
      Conserved Domains (1) summary
      cl28910
      Location:35 → 577
      MFS; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version

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