KLK4 kallikrein related peptidase 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KLK4provided by VGNC
Official Full Name: kallikrein related peptidase 4provided by VGNC
Primary source: VGNC:VGNC:42482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (106462891..106466451)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (105526312..105529783)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (106571164..106574633)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (106134079..106137554)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (105775605..105779075)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in amelogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix disassembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: kallikrein-4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197169.1 → NP_001184098.1 kallikrein-4 precursor

See identical proteins and their annotated locations for NP_001184098.1

Status: VALIDATED

Source sequence(s)

HM135452

UniProtKB/TrEMBL

A0A1R3UCN4, A0A8C0L4G7, A0A8C0YUV4, E2FGH4, F1Q0C3

Conserved Domains (1) summary

cd00190
Location:31 → 250

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...