SPTLC1 serine palmitoyltransferase long chain base subunit 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SPTLC1provided by VGNC
Official Full Name: serine palmitoyltransferase long chain base subunit 1provided by VGNC
Primary source: VGNC:VGNC:46779
See related: Ensembl:ENSCAFG00845017253
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (95597902..95649028)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (95445084..95510150)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (95710467..95775506)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (95224979..95289739)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (94951482..95016318)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine C-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sphingosine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine palmitoyltransferase 1; LOW QUALITY PROTEIN: serine palmitoyltransferase 1

XP_005616008.1

EC 2.3.1.50

XP_038322521.1

EC 2.3.1.50

XP_038322522.1

EC 2.3.1.50

XP_038322523.1

EC 2.3.1.50

XP_038322524.1

EC 2.3.1.50

XP_038383219.1

EC 2.3.1.50

XP_038383220.1

EC 2.3.1.50

XP_038383221.1

EC 2.3.1.50

XP_038383222.1

EC 2.3.1.50

XP_038447526.1

EC 2.3.1.50

XP_038447527.1

EC 2.3.1.50

XP_038447528.1

EC 2.3.1.50

XP_038447529.1

EC 2.3.1.50

XP_038459357.1

EC 2.3.1.50

XP_038459447.1

EC 2.3.1.50

XP_038511327.1

EC 2.3.1.50

XP_541308.2

EC 2.3.1.50

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

95597902..95649028

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038655399.1 → XP_038511327.1 LOW QUALITY PROTEIN: serine palmitoyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8C0K115, A0A8C0MMP0, A0A8C0QEE7, A0A8P0N598, A0A8P0T3J9

Related

ENSCAFP00845023943.1, ENSCAFT00845030523.1

Conserved Domains (1) summary

cl18945
Location:1 → 472

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049261.1 Alternate UMICH_Zoey_3.1

Range

95224979..95289739

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038466594.1 → XP_038322522.1 serine palmitoyltransferase 1 isoform X2
XM_038466593.1 → XP_038322521.1 serine palmitoyltransferase 1 isoform X1

Conserved Domains (1) summary

cl18945
Location:1 → 472

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038466595.1 → XP_038322523.1 serine palmitoyltransferase 1 isoform X3

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038466596.1 → XP_038322524.1 serine palmitoyltransferase 1 isoform X3

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049742.1 Alternate UNSW_CanFamBas_1.0

Range

94951482..95016318

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038591599.1 → XP_038447527.1 serine palmitoyltransferase 1 isoform X4
XM_038591598.1 → XP_038447526.1 serine palmitoyltransferase 1 isoform X1

Conserved Domains (1) summary

cl18945
Location:1 → 472

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038591600.1 → XP_038447528.1 serine palmitoyltransferase 1 isoform X5

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038591601.1 → XP_038447529.1 serine palmitoyltransferase 1 isoform X5

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049222.1 Alternate UU_Cfam_GSD_1.0

Range

95710467..95775506

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038527292.1 → XP_038383220.1 serine palmitoyltransferase 1 isoform X6

UniProtKB/TrEMBL

A0A8C0MJJ5, A0A8I3P1Z6, A0A8P0NPC9
XM_038527291.1 → XP_038383219.1 serine palmitoyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8C0K115, A0A8C0MMP0, A0A8C0QEE7, A0A8P0N598, A0A8P0T3J9

Conserved Domains (1) summary

cl18945
Location:1 → 472

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038527293.1 → XP_038383221.1 serine palmitoyltransferase 1 isoform X7

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038527294.1 → XP_038383222.1 serine palmitoyltransferase 1 isoform X7

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

95445084..95510150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005615951.3 → XP_005616008.1 serine palmitoyltransferase 1 isoform X8

UniProtKB/TrEMBL

A0A8C0MJJ5, A0A8I3P1Z6, A0A8P0NPC9

Conserved Domains (1) summary

cl18945
Location:1 → 442

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_541308.7 → XP_541308.2 serine palmitoyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8C0K115, A0A8C0MMP0, A0A8C0QEE7, A0A8P0N598, A0A8P0T3J9

Conserved Domains (1) summary

cl18945
Location:1 → 472

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038603429.1 → XP_038459357.1 serine palmitoyltransferase 1 isoform X9

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_038603519.1 → XP_038459447.1 serine palmitoyltransferase 1 isoform X9

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...