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    NOTCH2 notch receptor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 483148, updated on 5-Mar-2024

    Summary

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    Gene symbol
    NOTCH2
    Gene description
    notch receptor 2
    See related
    Ensembl:ENSCAFG00845007331
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NOTCH2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (57717260..57900443, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (56476088..56659161, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (57426245..57608931, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (56764520..56924479, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (56800478..56960572, complement)

    Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived protein 4 Neighboring gene disintegrin and metalloproteinase domain-containing protein 30 Neighboring gene D-3-phosphoglycerate dehydrogenase Neighboring gene uncharacterized LOC119863971 Neighboring gene hydroxymethylglutaryl-CoA synthase, mitochondrial-like Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene uncharacterized LOC102154106 Neighboring gene uncharacterized LOC111090694 Neighboring gene histone H2B type 2-E1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenic locus notch homolog protein 2
    Names
    Notch homolog 2
    notch 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051821.1 Reference ROS_Cfam_1.0

      Range
      57717260..57900443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038422869.1 → XP_038278797.1  neurogenic locus notch homolog protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SR20
      Related
      ENSCAFP00845010265.1, ENSCAFT00845013210.1
      Conserved Domains (11) summary
      smart00004
      Location:1421 → 1455
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1879 → 2066
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:182 → 218
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1943 → 1974
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1505 → 1534
      Notch; LNR domain
      pfam03154
      Location:2273 → 2467
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1540 → 1594
      NOD; NOTCH protein
      pfam07684
      Location:1619 → 1674
      NODP; NOTCH protein
      pfam11936
      Location:2381 → 2444
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1948 → 2040
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1659 → 1740
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049277.1 Alternate UMICH_Zoey_3.1

      Range
      56764520..56924479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038499365.1 → XP_038355293.1  neurogenic locus notch homolog protein 2 isoform X2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

      Range
      56800478..56960572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038626003.1 → XP_038481931.1  neurogenic locus notch homolog protein 2 isoform X1

      Conserved Domains (11) summary
      smart00004
      Location:1421 → 1455
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1879 → 2066
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:182 → 218
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1943 → 1974
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1505 → 1534
      Notch; LNR domain
      pfam03154
      Location:2273 → 2467
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1540 → 1594
      NOD; NOTCH protein
      pfam07684
      Location:1619 → 1674
      NODP; NOTCH protein
      pfam11936
      Location:2381 → 2444
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1948 → 2040
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1659 → 1740
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

      Range
      57426245..57608931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038561934.1 → XP_038417862.1  neurogenic locus notch homolog protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SR20
      Conserved Domains (11) summary
      smart00004
      Location:1421 → 1455
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1879 → 2066
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:182 → 218
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1943 → 1974
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1505 → 1534
      Notch; LNR domain
      pfam03154
      Location:2273 → 2467
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1540 → 1594
      NOD; NOTCH protein
      pfam07684
      Location:1619 → 1674
      NODP; NOTCH protein
      pfam11936
      Location:2381 → 2444
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1948 → 2040
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1659 → 1740
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      56476088..56659161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005630688.4 → XP_005630745.1  neurogenic locus notch homolog protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SR20
      Conserved Domains (11) summary
      smart00004
      Location:1421 → 1455
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1879 → 2066
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:182 → 218
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1943 → 1974
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1505 → 1534
      Notch; LNR domain
      pfam03154
      Location:2273 → 2467
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1540 → 1594
      NOD; NOTCH protein
      pfam07684
      Location:1619 → 1674
      NODP; NOTCH protein
      pfam11936
      Location:2381 → 2444
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1948 → 2040
      Ank_2; Ankyrin repeats (3 copies)
      cd21703
      Location:1659 → 1740
      JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins
    Nucleotide Protein
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