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    ADGRA2 adhesion G protein-coupled receptor A2 [ Canis lupus familiaris (dog) ]

    Gene ID: 482853, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ADGRA2provided by VGNC
    Official Full Name
    adhesion G protein-coupled receptor A2provided by VGNC
    Primary source
    VGNC:VGNC:37632
    See related
    Ensembl:ENSCAFG00845013679
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    GPR124
    Orthologs
    human mouse all
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    Genomic context

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    See ADGRA2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (29448402..29482344, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (28066037..28099848, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (28285068..28320567, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (27668324..27703792, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (28245885..28281475, complement)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 1 Neighboring gene BRF2 RNA polymerase III transcription initiation factor subunit Neighboring gene pyridoxal phosphate binding protein Neighboring gene proline-rich protein 2-like Neighboring gene ER lipid raft associated 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Wnt signalosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor A2; LOW QUALITY PROTEIN: adhesion G protein-coupled receptor A2
    Names
    G protein-coupled receptor 124

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      29448402..29482344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689901.1 → XP_038545829.1  adhesion G protein-coupled receptor A2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJK1, A0A8C0JN31, A0A8C0NJM8, A0A8C0SEU4, A0A8I3NTF7
      Related
      ENSCAFP00845019177.1, ENSCAFT00845024397.1
      Conserved Domains (7) summary
      TIGR00864
      Location:161 → 238
      PCC; polycystin cation channel protein
      sd00031
      Location:85 → 108
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:765 → 1084
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:707 → 751
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:87 → 143
      LRR_8; Leucine rich repeat
      cl02422
      Location:350 → 416
      HRM; Hormone receptor domain
      cl11960
      Location:256 → 342
      Ig; Immunoglobulin domain

    2. XM_038689902.1 → XP_038545830.1  adhesion G protein-coupled receptor A2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JKF4, A0A8C0NIJ9, A0A8P0SRE1
      Conserved Domains (8) summary
      TIGR00864
      Location:116 → 193
      PCC; polycystin cation channel protein
      sd00031
      Location:64 → 87
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:720 → 1039
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:662 → 706
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:45 → 98
      LRR_8; Leucine rich repeat
      cd00096
      Location:255 → 259
      Ig; Ig strand D [structural motif]
      cl02422
      Location:305 → 371
      HRM; Hormone receptor domain
      cl11960
      Location:211 → 297
      Ig; Immunoglobulin domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      27668324..27703792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038497633.1 → XP_038353561.1  adhesion G protein-coupled receptor A2 isoform X1

      Conserved Domains (7) summary
      TIGR00864
      Location:161 → 238
      PCC; polycystin cation channel protein
      sd00031
      Location:85 → 108
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:765 → 1084
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:707 → 751
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:87 → 143
      LRR_8; Leucine rich repeat
      cl02422
      Location:350 → 416
      HRM; Hormone receptor domain
      cl11960
      Location:256 → 342
      Ig; Immunoglobulin domain

    2. XM_038497634.1 → XP_038353562.1  adhesion G protein-coupled receptor A2 isoform X2

      Conserved Domains (8) summary
      TIGR00864
      Location:116 → 193
      PCC; polycystin cation channel protein
      sd00031
      Location:64 → 87
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:720 → 1039
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:662 → 706
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:45 → 98
      LRR_8; Leucine rich repeat
      cd00096
      Location:255 → 259
      Ig; Ig strand D [structural motif]
      cl02422
      Location:305 → 371
      HRM; Hormone receptor domain
      cl11960
      Location:211 → 297
      Ig; Immunoglobulin domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      28245885..28281475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038624148.1 → XP_038480076.1  adhesion G protein-coupled receptor A2 isoform X1

      Conserved Domains (7) summary
      TIGR00864
      Location:161 → 238
      PCC; polycystin cation channel protein
      sd00031
      Location:85 → 108
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:765 → 1084
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:707 → 751
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:87 → 143
      LRR_8; Leucine rich repeat
      cl02422
      Location:350 → 416
      HRM; Hormone receptor domain
      cl11960
      Location:256 → 342
      Ig; Immunoglobulin domain

    2. XM_038624149.1 → XP_038480077.1  adhesion G protein-coupled receptor A2 isoform X2

      Conserved Domains (8) summary
      TIGR00864
      Location:116 → 193
      PCC; polycystin cation channel protein
      sd00031
      Location:64 → 87
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:720 → 1039
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:662 → 706
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:45 → 98
      LRR_8; Leucine rich repeat
      cd00096
      Location:255 → 259
      Ig; Ig strand D [structural motif]
      cl02422
      Location:305 → 371
      HRM; Hormone receptor domain
      cl11960
      Location:211 → 297
      Ig; Immunoglobulin domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      28285068..28320567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038560101.1 → XP_038416029.1  adhesion G protein-coupled receptor A2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJK1, A0A8C0NJM8

    2. XM_038560102.1 → XP_038416030.1  adhesion G protein-coupled receptor A2 isoform X2

      UniProtKB/TrEMBL
      A0A8P0SRE1

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      28066037..28099848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_539968.7 → XP_539968.7  LOW QUALITY PROTEIN: adhesion G protein-coupled receptor A2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJK1, A0A8C0JN31, A0A8C0NJM8, A0A8C0SEU4, A0A8I3NTF7
      Conserved Domains (7) summary
      TIGR00864
      Location:161 → 238
      PCC; polycystin cation channel protein
      sd00031
      Location:85 → 108
      LRR_1; leucine-rich repeat [structural motif]
      cd15998
      Location:765 → 1084
      7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:707 → 751
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:87 → 143
      LRR_8; Leucine rich repeat
      cl02422
      Location:350 → 416
      HRM; Hormone receptor domain
      cl11960
      Location:256 → 342
      Ig; Immunoglobulin domain
    Nucleotide Protein
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