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    NRF1 nuclear respiratory factor 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 482260, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NRF1provided by VGNC
    Official Full Name
    nuclear respiratory factor 1provided by VGNC
    Primary source
    VGNC:VGNC:43966
    See related
    Ensembl:ENSCAFG00845019891
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NRF1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (6848014..6983992, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (6770310..6906180, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (6940039..7075975, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (7053598..7189532, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (6795757..6931636, complement)

    Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102151305 Neighboring gene small nucleolar RNA U13 Neighboring gene microRNA mir-96 Neighboring gene microRNA mir-182 Neighboring gene small lysine rich protein 1 Neighboring gene striatin interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear respiratory factor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051818.1 Reference ROS_Cfam_1.0

      Range
      6848014..6983992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038686157.1 → XP_038542085.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. XM_038686160.1 → XP_038542088.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Related
      ENSCAFP00845027442.1, ENSCAFT00845035046.1
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    3. XM_038686158.1 → XP_038542086.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    4. XM_038686159.1 → XP_038542087.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    5. XM_038686163.1 → XP_038542091.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0LG37, A0A8C0S316, A0A8I3P6Z4, A0A8I3PC65, A0A8P0PE74
      Related
      ENSCAFP00845027522.1, ENSCAFT00845035160.1
      Conserved Domains (2) summary
      pfam10492
      Location:450 → 493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    6. XM_038686156.1 → XP_038542084.1  nuclear respiratory factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PFN5
      Conserved Domains (2) summary
      pfam10492
      Location:499 → 542
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    7. XM_038686162.1 → XP_038542090.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S3C1, A0A8I3S1G3
      Related
      ENSCAFP00845027614.1, ENSCAFT00845035274.1
      Conserved Domains (1) summary
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049274.1 Alternate UMICH_Zoey_3.1

      Range
      7053598..7189532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038494243.1 → XP_038350171.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. XM_038494246.1 → XP_038350174.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    3. XM_038494244.1 → XP_038350172.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    4. XM_038494245.1 → XP_038350173.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    5. XM_038494248.1 → XP_038350176.1  nuclear respiratory factor 1 isoform X4

      Conserved Domains (2) summary
      pfam10492
      Location:450 → 493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    6. XM_038494242.1 → XP_038350170.1  nuclear respiratory factor 1 isoform X1

      Conserved Domains (2) summary
      pfam10492
      Location:499 → 542
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    7. XM_038494247.1 → XP_038350175.1  nuclear respiratory factor 1 isoform X3

      Conserved Domains (1) summary
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

      Range
      6795757..6931636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038620472.1 → XP_038476400.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. XM_038620475.1 → XP_038476403.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    3. XM_038620473.1 → XP_038476401.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    4. XM_038620474.1 → XP_038476402.1  nuclear respiratory factor 1 isoform X2

      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    5. XM_038620477.1 → XP_038476405.1  nuclear respiratory factor 1 isoform X4

      Conserved Domains (2) summary
      pfam10492
      Location:450 → 493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    6. XM_038620471.1 → XP_038476399.1  nuclear respiratory factor 1 isoform X1

      Conserved Domains (2) summary
      pfam10492
      Location:499 → 542
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    7. XM_038620476.1 → XP_038476404.1  nuclear respiratory factor 1 isoform X3

      Conserved Domains (1) summary
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

      Range
      6940039..7075975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038556538.1 → XP_038412466.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. XM_038556541.1 → XP_038412469.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    3. XM_038556539.1 → XP_038412467.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    4. XM_038556540.1 → XP_038412468.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    5. XM_038556543.1 → XP_038412471.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0LG37, A0A8C0S316, A0A8I3P6Z4, A0A8I3PC65, A0A8P0PE74
      Conserved Domains (2) summary
      pfam10492
      Location:450 → 493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    6. XM_038556537.1 → XP_038412465.1  nuclear respiratory factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PFN5
      Conserved Domains (2) summary
      pfam10492
      Location:499 → 542
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    7. XM_038556542.1 → XP_038412470.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S3C1, A0A8I3S1G3
      Conserved Domains (1) summary
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      6770310..6906180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014119030.3 → XP_013974505.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. XM_014119036.3 → XP_013974511.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    3. XM_014119035.3 → XP_013974510.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    4. XM_038435664.1 → XP_038291592.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S352, A0A8I3PAK4
      Conserved Domains (2) summary
      pfam10492
      Location:503 → 546
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    5. XM_022427239.2 → XP_022282947.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0LG37, A0A8C0S316, A0A8I3P6Z4, A0A8I3PC65, A0A8P0PE74
      Conserved Domains (2) summary
      pfam10492
      Location:450 → 493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    6. XM_022427236.2 → XP_022282944.1  nuclear respiratory factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0PFN5
      Conserved Domains (2) summary
      pfam10492
      Location:499 → 542
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    7. XM_022427238.2 → XP_022282946.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C0PFN5, A0A8C0S3C1, A0A8I3S1G3
      Conserved Domains (1) summary
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    Nucleotide Protein
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